| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Immunoreactivity of GLUT5 and GLUT8 was located in epithelial cells of the choroid plexus and ependymal cells. Immunoreactivity of GLUT8 was located in the cytoplasm of astrocytes and microglia. It is likely that intravascular substance including sugars was transported to periventricular areas. These findings suggest that intravascular fructose migrates to periventricular areas. Culture experiments under high concentration of fructose for short and long periods were conducted by evaluating not only survival rates, production of reactive oxygen species (ROS), and effects on the outgrowth of cultured neurons, but also survival rates and ROS production of cultured microglia. Although the survival rate of cultured neurons for a long period had decreased slightly, other parameters were significantly changed.
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