| Project/Area Number |
26430060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
Masaki Takao 埼玉医科大学, 医学部, 教授 (50245487)
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| Co-Investigator(Kenkyū-buntansha) |
美原 盤 公益財団法人脳血管研究所, その他部局等, 研究員(移行) (30190721)
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| Research Collaborator |
NAKANO Yuta
Bernardino Ghetti
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プリオン / 軸索輸送 / クロイツフェルト・ヤコブ病 / アミロイド / タウ / 神経変性疾患 / 変性疾患 / 神経病理 / 認知症疾患 |
|---|
| Outline of Final Research Achievements |
In order to understand the propagation of prion protein of human prion diseases, we neuropathologically analyzed human brain tissue using anti-prion immunohistochemistry. Although axonal immunoreactivity (ir) was reported in the individuals with specific Gerstmann-Straussler-Scheinker disease (GSS) cases, there was no clear axonal anti-PrP-ir in sporadic and genetic Creutzfeldt-Jakob disease (CJD) as well as GSS. In contrast, anti-PrP-ir was observed along the neuronal cell soma, dendrites and axons in the hippocampus and temporal cortex in most of analyzed cases. Perineuronal PrP-ir was considered as characteristic findings in VV2 prion disease. Since there were no VV2 cases in the present study, we need more analysis the meaning of the findings.
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