Neuropathlogic analysis of axon and tau protein of human prion diseases
Project/Area Number |
26430060
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Saitama Medical University |
Principal Investigator |
Masaki Takao 埼玉医科大学, 医学部, 教授 (50245487)
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Co-Investigator(Kenkyū-buntansha) |
美原 盤 公益財団法人脳血管研究所, その他部局等, 研究員(移行) (30190721)
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Research Collaborator |
NAKANO Yuta
Bernardino Ghetti
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | プリオン / 軸索輸送 / クロイツフェルト・ヤコブ病 / アミロイド / タウ / 神経変性疾患 / 変性疾患 / 神経病理 / 認知症疾患 |
Outline of Final Research Achievements |
In order to understand the propagation of prion protein of human prion diseases, we neuropathologically analyzed human brain tissue using anti-prion immunohistochemistry. Although axonal immunoreactivity (ir) was reported in the individuals with specific Gerstmann-Straussler-Scheinker disease (GSS) cases, there was no clear axonal anti-PrP-ir in sporadic and genetic Creutzfeldt-Jakob disease (CJD) as well as GSS. In contrast, anti-PrP-ir was observed along the neuronal cell soma, dendrites and axons in the hippocampus and temporal cortex in most of analyzed cases. Perineuronal PrP-ir was considered as characteristic findings in VV2 prion disease. Since there were no VV2 cases in the present study, we need more analysis the meaning of the findings.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.2016
Author(s)
Takatsuki H, Fuse T, Nakagaki T, Mori T, Mihara B, Takao M, Iwasaki Y, Yoshida M, Murayama S, Atarashi R, Nishida N, Satoh K.
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Journal Title
EBioMedicine.
Volume: 12
Pages: 150-155
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Significant association of cadaveric dura mater grafting with subpial Aβ deposition and meningeal amyloid angiopathy.2016
Author(s)
Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Sanjo N, Mizusawa H, Yamada M.
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Journal Title
Acta Neuropathol.
Volume: 132(2)
Issue: 2
Pages: 313-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 Are Identical in Transmission Properties.2015
Author(s)
Kobayashi A, Matsuura Y, Iwaki T, Iwasaki Y, Yoshida M, Takahashi H, Murayama S, Takao M, Kato S, Yamada M, Mohri S, Kitamoto T.
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Journal Title
Brain Pathol
Volume: in press
Issue: 1
Pages: 95-101
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases.2015
Author(s)
Takatsuki H, Satoh K, Sano K, Fuse T, Nakagaki T, Mori T, Ishibashi D, Mihara B, Takao M, Iwasaki Y, Yoshida M, Atarashi R, Nishida N.
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Journal Title
PLoS One
Volume: 10
Issue: 6
Pages: 0126930-0126930
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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