| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
There are increasing evidence that patients with diabetic mellitus (DM) have a higher prevalence to major depressive disorder than the general population; however, the biological mechanisms are still unclear. Here, we examined the effect of experimental DM on the emotional function and the metabolites profile in the brain in mice. DM mice exhibited the higher levels of blood glucose and the lower body weights. DM mice showed the abnormal behaviors. The brain metabolite levels were also altered in DM mice. The treatment with insulin dose-dependently and significantly improved these abnormalities. We found that the trophic factor receptor-mediated signaling was a candidate associated with the emotional disability in DM mice. Overall, we suggest the possibility that DM affects the emotional function mediated, at least in part, by disrupting the regulation the metabolites-associated signaling.
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