• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The elucidation of functions of CLAC-P/collagen XXV in neuromuscular development and synapse formation

Research Project

Project/Area Number 26430064
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe University of Tokyo

Principal Investigator

Wakabayashi Tomoko  東京大学, 大学院医学系研究科(医学部), 助教 (20530330)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords運動ニューロン / 神経発生
Outline of Final Research Achievements

We previously identified that CLAC-P/collagen XXV is essential for intramuscular innervation of motor neurons during development. In this study, we generated tissue-specific Col25a1 knockout mice and revealed that collagen XXV expressed in developing skeletal muscle but not in motor neuron is indispensable for neuromuscular development. mRNA expression of collagen XXV in skeletal muscle is downregulated by muscle electrical activity arising from motor innervation. We also identified type IIa RPTPs, which are known to be involved in synapse formation in the CNS and motor axon elongation/regeneration, as possible interactors.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Presentation] Identification of the interactor of CLAC-P/Collagen type XXV in motor nerve innervation of skeletal muscles2016

    • Author(s)
      Haruka Munezane, Hiroaki Oizumi, Tomoyuki Yoshida, Tomoko Wakabayashi, Takeshi Iwastubo
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, CA (U.S.A.)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The elucidation of the physiological function of CLAC-P/ collagen XXV in neuromuscular development2016

    • Author(s)
      Haruka Munezane, Hiroaki Oizumi, Tomoyuki Yoshida, Tomoko Wakabayashi, Takeshi Iwastubo
    • Organizer
      The 47th NIPS International Symposium
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The elucidation of molecular mechanism of CLAC-P/Collagen type XXV in motor innervation of skeletal muscle2015

    • Author(s)
      Haruka Munezane, Hiroaki Oizumi, Tomoyuki Yoshida, Tomoko Wakabayashi, Takeshi Iwastubo
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Collagen XXV/CLAC-Pの骨格筋における発現制御に関する研究2015

    • Author(s)
      西尾 周、大泉 寛明、宗實 悠佳、若林 朋子、岩坪 威
    • Organizer
      第34回 日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県青森市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Roles in Neuromuscular Development of CLAC-P/Collagen Type XXV: A Molecule Originally Identified in Alzheimer Brains2015

    • Author(s)
      Tomoko Wakabayashi
    • Organizer
      Gordon Research Conference: Collagen
    • Place of Presentation
      New London, NH ( U.S.A.)
    • Year and Date
      2015-07-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] アルツハイマー病脳老人斑構成成分 CLAC-P/CollagenXXV の 中枢神経系における生理機能の解明2014

    • Author(s)
      宗実悠佳、吉田知之、若林朋子、岩坪威
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Research-status Report
  • [Presentation] CLAC-P/collagen type XXV in muscle, but not in motor neurons, is required for intramuscular development of motor axons2014

    • Author(s)
      Oizumi H, Tanaka T, Nishio S, Munezane H, Hashimoto T, Harada A, Wakabayashi T, Iwatsubo T
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, U.S.A.
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi