Elucidation of the mechanisms of chronic pain by PAC1 receptor and drug discovery.
Project/Area Number |
26430067
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | University of Toyama |
Principal Investigator |
TAKASAKI ICHIRO 富山大学, 大学院理工学研究部(工学), 准教授 (00397176)
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Co-Investigator(Renkei-kenkyūsha) |
KURIHARA TAKASHI 鹿児島大学, 医歯学総合研究科(医学), 准教授 (60282745)
TOYOOKA NAOKI 富山大学, 大学院理工学研究部(工学), 教授 (10217565)
GOUDA HIROAKI 昭和大学, 薬学部, 教授 (60276160)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | PACAP / PAC1受容体 / アロディニア / 脊髄後角 / マイクロアレイ / 創薬 / 慢性疼痛 / 神経障害性疼痛 / ケモカイン / 核内受容体 / アンタゴニスト / Maxadilan |
Outline of Final Research Achievements |
Activation of spinal PAC1 receptor induces long-lasting mechanical allodynia in mice. In this study, we analyzed the involvement spinal Cyr61 which expression is increased by PAC1 receptor activation on the pain. Intrathecal injection of Cyr61 recombinant protein induced mechanical allodynia. Cyr61 protein increased the expression of chemokine CCL2 and CCL7 mRNA via integrin beta-1 in the astrocyte. The present results suggest that spinal PAC1-Cyr61-chemokine signaling are involved in the chronic pain and that integrin and/or chemokine receptors may be useful target for developing new analgesics.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Neuromodulatory Effect of Gαs- or Gαq-Coupled G-Protein-Coupled Receptor on NMDA Receptor Selectively Activates the NMDA Receptor/Ca2+/Calcineurin/cAMP Response Element-Binding Protein-Regulated Transcriptional Coactivator 1 Pathway to Effectively Induce Brain-Derived Neurotrophic Factor Expression in Neurons.2015
Author(s)
Fukuchi M, Tabuchi A, Kuwana Y, Watanabe S, Inoue M, Takasaki I, Izumi H, Tanaka A, Inoue R, Mori H, Komatsu H, Takemori H, Okuno H, Bito H, Tsuda M.
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Journal Title
J Neurosci
Volume: 35 (14)
Pages: 5606-5624
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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