| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Synaptic plasticity is widely accepted to provide a cellular basis for learning and memory. An attractive hypothesis for synapse specificity of long-term memory (LTM) is synaptic tagging: synaptic activity generates a tag, which captures the plasticity-related proteins derived outside of synapses. Previously we have been reported that neuropsin, a plasticity-related extracellular protease, was involved in synaptic tag setting. In the present study, we tested the hypothesis that neuropsin was engaged in behavioral tagging for LTM in vivo. Behaviorally, weak training inhibitory passive avoidance task (IA) or spatial object recognition task (SOR), which induces short-term memory (STM) but not LTM, can be consolidated into LTM by exposing animals to novel but not familiar environment 1 h before training. We found that neuropsin deficient mouse impaired such transformation short-term into long-term memory. These results suggest neuropsin as a molecule of behavioral tag setting in vivo.
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