The analysis of late associativity.
Project/Area Number |
26430073
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Maebashi Institute of Technology |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 連合性長期記憶 / シナプスタグ / 長期記憶 / 短期記憶 / ニューロプシン / 行動タグ / シナプス / 海馬 / シナプス・タギング / 行動 / 経験 |
Outline of Final Research Achievements |
Synaptic plasticity is widely accepted to provide a cellular basis for learning and memory. An attractive hypothesis for synapse specificity of long-term memory (LTM) is synaptic tagging: synaptic activity generates a tag, which captures the plasticity-related proteins derived outside of synapses. Previously we have been reported that neuropsin, a plasticity-related extracellular protease, was involved in synaptic tag setting. In the present study, we tested the hypothesis that neuropsin was engaged in behavioral tagging for LTM in vivo. Behaviorally, weak training inhibitory passive avoidance task (IA) or spatial object recognition task (SOR), which induces short-term memory (STM) but not LTM, can be consolidated into LTM by exposing animals to novel but not familiar environment 1 h before training. We found that neuropsin deficient mouse impaired such transformation short-term into long-term memory. These results suggest neuropsin as a molecule of behavioral tag setting in vivo.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation2017
Author(s)
Makito Haruta, Naoya Kamiyama, Shun Nakajima, Mayumi Motoyama, Mamiko Kawahara, Yasumi Ohta, Atsushi Yamasaki, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Yasuyuki Ishikawa, Takashi Tokuda, Hitoshi Hashimoto and Jun Ohta
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Journal Title
Japanese Journal of Applied Physics
Volume: 56
NAID
Related Report
Peer Reviewed
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