| Project/Area Number |
26430084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Sugimoto Chie 北海道大学, 医学研究科, 助教 (60469955)
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| Co-Investigator(Kenkyū-buntansha) |
若尾 宏 獨協医科大学, 医学部, 特任教授 (10280950)
藤田 博美 獨協医科大学, 医学部, 特任教授 (60142931)
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| Research Collaborator |
KURODA Marcelo J. Tulane University, Professor
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | MAIT細胞 / 自然免疫型T細胞 / 動物モデル / 自然免疫系T細胞 / アカゲザル |
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| Outline of Final Research Achievements |
MAIT cells are a novel subset of innate like T cells which could be associated with susceptibility to opportunistic infections in immune compromised patients. Although MAIT cells are very abundant in humans, there is no suitable animal model for studying MAIT cells due to a very low frequency in laboratory mice. The aim of this study was to establish MAIT animal models. (1) Rhesus monkey model for AIDS-related opportunistic infections: We have detected MAIT cells in peripheral blood from healthy rhesus monkeys by using anti-human antibodies. That frequency was similar to humans. (2) Novel MAIT mouse model: We have established iPS cells derived from MAIT cells in C57BL/6 mice and observed that the iPS cells re-differenciated into MAIT cells using the OP9 feeder cell system. The mouse MAIT-iPS cells will be applied to construct novel mouse MAIT models for future studies.
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