Research Project
Grant-in-Aid for Scientific Research (C)
APJ is a G protein-coupled receptor and highly expressed in various cardiovascular tissues. Although the physiological function of APJ on vascular endothelial cells was identified as a hypotensive system, its action on vascular smooth muscle cells (VSMCs) is still unclear. To examine the physiological role of APJ on VSMCs, we generated transgenic mice expressing APJ specifically in VSMCs, called SMA-APJ. Interestingly, I found sustained bradycardia and the development of coronary stenosis in SMA-APJ following apelin administration. An ex vivo assay using the Easy Magnus System revealed that the aorta of SMA-APJ was contracted intensively when co-stimulated with apelin and noradrenaline, a ligand of α1-adrenergic receptor (α1-AR).
All 2017 2016 2015 2014 Other
All Journal Article (16 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 16 results, Open Access: 10 results, Acknowledgement Compliant: 6 results) Presentation (35 results) (of which Int'l Joint Research: 1 results, Invited: 3 results) Book (1 results) Remarks (1 results)
Journal of Biochemistry
Volume: 161 Pages: 255-258
10.1093/jb/mvw095
Volume: 161 Pages: 155-158
10.1093/jb/mvw090
40021133445
PLoS ONE
Volume: - Issue: 11 Pages: e0166974-e0166974
10.1371/journal.pone.0166974
Proc Natl Acad Sci USA
Volume: 113 Issue: 38 Pages: 10702-10707
10.1073/pnas.1604527113
Stem Cell Reviews
Volume: 12 Issue: 5 Pages: 530-542
10.1007/s12015-016-9668-2
Journal of Biological Chemistry
Volume: 291 Issue: 21 Pages: 11241-11251
10.1074/jbc.m115.699009
J. Biol. Chem.
Volume: 291 Issue: 5 Pages: 2237-2245
10.1074/jbc.m115.684514
120007128484
American Journal of Physiology-Heart and circulatory physiology
Volume: 印刷中 Issue: 8 Pages: 931-941
10.1152/ajpheart.00703.2013
PLoS One
Volume: 10 Issue: 6 Pages: e0129484-e0129484
10.1371/journal.pone.0129484
Physiol. Rep.
Volume: 3 Issue: 9 Pages: e12542-e12542
10.14814/phy2.12542
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Volume: 1006 Pages: 93-98
10.1016/j.jchromb.2015.10.018
Sci. Adv.
Volume: 1 Issue: 11
10.1126/sciadv.1500615
Laboratory Investigation
Volume: 94 Issue: 3 Pages: 321-330
10.1038/labinvest.2013.146
J. Recept. Signal Transduct. Res.
Volume: 34 Issue: 4 Pages: 307-312
10.3109/10799893.2014.885050
J Recept Signal Transduc
Volume: in press Issue: 4 Pages: 299-306
10.3109/10799893.2014.896380
J. Recept. Signal Transduct.
Volume: 34 Issue: 5 Pages: 401-409
10.3109/10799893.2014.908917
http://www.tsukuba.ac.jp/attention-research/p201602041400.html