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Cooperative action of APJ and alpha1A-adrenrgic receptor in vascular smooth muscle cells induces intensive vasoconstriction

Research Project

Project/Area Number 26430086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory animal science
Research InstitutionUniversity of Tsukuba

Principal Investigator

ISHIDA Junji  筑波大学, 生命領域学際研究センター, 講師 (30323257)

Co-Investigator(Renkei-kenkyūsha) YAGAMI Ken-ichi  筑波大学, 医学医療系, 教授 (40166476)
SUGIYAMA Fumihiro  筑波大学, 医学医療系, 教授 (90226481)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsAPJ受容体 / 血管収縮 / アドレナリン受容体 / トランスジェニックマウス / ノックアウトマウス / シグナル伝達 / 受容体間相互作用 / 分子間相互作用
Outline of Final Research Achievements

APJ is a G protein-coupled receptor and highly expressed in various cardiovascular tissues. Although the physiological function of APJ on vascular endothelial cells was identified as a hypotensive system, its action on vascular smooth muscle cells (VSMCs) is still unclear. To examine the physiological role of APJ on VSMCs, we generated transgenic mice expressing APJ specifically in VSMCs, called SMA-APJ. Interestingly, I found sustained bradycardia and the development of coronary stenosis in SMA-APJ following apelin administration. An ex vivo assay using the Easy Magnus System revealed that the aorta of SMA-APJ was contracted intensively when co-stimulated with apelin and noradrenaline, a ligand of α1-adrenergic receptor (α1-AR).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (53 results)

All 2017 2016 2015 2014 Other

All Journal Article (16 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 16 results,  Open Access: 10 results,  Acknowledgement Compliant: 6 results) Presentation (35 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells.2017

    • Author(s)
      Ishimaru, T., Ishida, J., Kim, JD., Mizukami, H., Hara, K., Hashimoto, M., Yagami, KI., Sugiyama, F., and Fukamizu, A.
    • Journal Title

      Journal of Biochemistry

      Volume: 161 Pages: 255-258

    • DOI

      10.1093/jb/mvw095

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hydralazine is involved in tele-methylhistamine metabolism by inhibiting monoamine oxidase B in pregnancy-associated hypertensive mice.2017

    • Author(s)
      Kawasaki, S., Kako, K., Nagashima, Y., Kanou, A., Ishida, J., and Fukamizu, A.
    • Journal Title

      Journal of Biochemistry

      Volume: 161 Pages: 155-158

    • DOI

      10.1093/jb/mvw090

    • NAID

      40021133445

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Long-Range Control of Renin Gene Expression in Tsukuba Hypertensive Mice2016

    • Author(s)
      Aki Ushiki, Hitomi Matsuzaki, Junji Ishida, Akiyoshi Fukamizu and Keiji Tanimoto
    • Journal Title

      PLoS ONE

      Volume: - Issue: 11 Pages: e0166974-e0166974

    • DOI

      10.1371/journal.pone.0166974

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading.2016

    • Author(s)
      Egashira Y, Takase M, Watanabe S, Ishida J, Fukamizu A, Kaneko R, Yanagawa Y, Takamori S.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 113 Issue: 38 Pages: 10702-10707

    • DOI

      10.1073/pnas.1604527113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Embryonic intra-aortic clusters undergo myeloid differentiation mediated by mesonephros-derived CSF1 in mouse.2016

    • Author(s)
      Sasaki T, Tanaka Y, Kulkeaw K, Yumine-Takai A, Tan KS, Nishinakamura R, Ishida J, Fukamizu A, Sugiyama D.
    • Journal Title

      Stem Cell Reviews

      Volume: 12 Issue: 5 Pages: 530-542

    • DOI

      10.1007/s12015-016-9668-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lactation is a Risk Factor of Postpartum Heart Failure in Mice with Cardiomyocyte-specific Apelin Receptor (APJ) Overexpression.2016

    • Author(s)
      Murata, K., Ishida, J., Ishimaru, T., Mizukami, H., Hamada, J., Saito, C., and Fukamizu, A.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Issue: 21 Pages: 11241-11251

    • DOI

      10.1074/jbc.m115.699009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe hypomyelination and developmental defects are caused in mice lacking protein arginine methyltransferase 1 (PRMT1) in the central nervous system.2016

    • Author(s)
      Hashimoto, M., Murata, M., Ishida, J., Kanou, A., Kasuya, Y., and Fukamizu, A.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 5 Pages: 2237-2245

    • DOI

      10.1074/jbc.m115.684514

    • NAID

      120007128484

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible involvement of downregulation of the apelin-APJ system in doxorubicin-induced cardiotoxicity2015

    • Author(s)
      Hamada, J., Baasanjav, A., Ono, N., Murata, K., Kako, K., Ishida, J., Fukamizu, A.
    • Journal Title

      American Journal of Physiology-Heart and circulatory physiology

      Volume: 印刷中 Issue: 8 Pages: 931-941

    • DOI

      10.1152/ajpheart.00703.2013

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways2015

    • Author(s)
      Kato H, Ishida J, Matsusaka T, Ishimaru T, Tanimoto K, Sugiyama F, Yagami K, Nangaku M, Fukamizu A
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0129484-e0129484

    • DOI

      10.1371/journal.pone.0129484

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Angiotensin II accelerates mammary gland development independently of high blood pressure in pregnancy-associated hypertensive mice.2015

    • Author(s)
      Murata, K., Baasanjav, A., Kwon, C., Hashimoto, M., Ishida, J., and Fukamizu, A.
    • Journal Title

      Physiol. Rep.

      Volume: 3 Issue: 9 Pages: e12542-e12542

    • DOI

      10.14814/phy2.12542

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of ethanolamine altering in fetuses of pregnancy-associated hypertensive mice treated with vasodepressors by using UPLC and MALDI-TOF/MS.2015

    • Author(s)
      Kako, K., Nakamura, A., Nagashima, Y., Ishida, J., Fukamizu, A.
    • Journal Title

      J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.

      Volume: 1006 Pages: 93-98

    • DOI

      10.1016/j.jchromb.2015.10.018

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination.2015

    • Author(s)
      Kim, J.D., Park, K.E., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M,. Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., Fukamizu, A.
    • Journal Title

      Sci. Adv.

      Volume: 1 Issue: 11

    • DOI

      10.1126/sciadv.1500615

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Truncated Cables1 causes agenesis of the corpus callosum in mice2014

    • Author(s)
      Mizuno S, Dinh T, Mizobuchi A, Iseki H, Mizuno-Iijima S, Kim J-D, Ishida J, Matsuda Y, Kunita S, Fukamizu A, Yagami K, Sugiyama F
    • Journal Title

      Laboratory Investigation

      Volume: 94 Issue: 3 Pages: 321-330

    • DOI

      10.1038/labinvest.2013.146

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] GPR39-1b, the 5-transmembrane isoform of GPR39 interacts with neurotensin receptor NTSR1 and modifies its function.2014

    • Author(s)
      Yasuda, SI., and Ishida, J.
    • Journal Title

      J. Recept. Signal Transduct. Res.

      Volume: 34 Issue: 4 Pages: 307-312

    • DOI

      10.3109/10799893.2014.885050

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] p38 mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.2014

    • Author(s)
      Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y.
    • Journal Title

      J Recept Signal Transduc

      Volume: in press Issue: 4 Pages: 299-306

    • DOI

      10.3109/10799893.2014.896380

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice.2014

    • Author(s)
      Tanimoto K, Kanafusa S, Ushiki A, Matsuzaki H, Ishida J, Sugiyama F, Fukamizu A
    • Journal Title

      J. Recept. Signal Transduct.

      Volume: 34 Issue: 5 Pages: 401-409

    • DOI

      10.3109/10799893.2014.908917

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] ホスホリパーゼ活性を持つアルギニンメチル化酵素の小脳機能に対する役割2016

    • Author(s)
      金 俊達、石田純治、加香孝一郎、濱田樹理、深水昭吉
    • Organizer
      第10回 炎症・脂質代謝・メタボリサーチフォーラム
    • Place of Presentation
      東京大学山上会館(東京都 文京区)
    • Year and Date
      2016-02-13
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒスタミンのH3受容体を介した心腎病態に対する作用の検討2015

    • Author(s)
      野口 和之,石田 純治,石丸 友博,川崎 祥平,金 俊達,権 哲源,加香 孝一郎,山縣 邦弘,深水 昭吉
    • Organizer
      Advans研究会 2015
    • Place of Presentation
      ホテルグランドパレス九段下(東京都、千代田区)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Protective effect of histamine on the pathology in a mouse model of cardio-renal association2015

    • Author(s)
      Junji Ishida, Kazuyuki Noguchi, Tomohiro Ishimaru, Shohei Kawasaki, Chulwon Kwon, Jun-Dal Kim, Kunihiro Yamagata, Akiyoshi Fukamizu
    • Organizer
      International Society for Heart Research 2015
    • Place of Presentation
      Kobe Convention Center (Hyogo, Kobe)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] アルギニンメチル基転移酵素 PRMT1 による心機能制御機構の解明2015

    • Author(s)
      村田 知弥、陸 偉哲、橋本 美涼、石田 純治、深水 昭吉
    • Organizer
      第19回 日本心血管内分泌代謝学
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 降圧剤によるモノアミンオキシダーゼの阻害作用に関する研究2015

    • Author(s)
      川崎 祥平、加香 孝一郎、永島 裕介、石田 純治、深水 昭吉
    • Organizer
      第19回 日本心血管内分泌代謝学
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管内皮タンパク質アルギニンメチル基転移酵素・PRMT1の機能解析2015

    • Author(s)
      石丸 友博、石田 純治、金 俊達、仲島 由佳、橋本 美涼、水上 早瀬、杉山 文博、八神 健一、深水 昭吉
    • Organizer
      第19回 日本心血管内分泌代謝学
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Maintenance of phosphatidylcholine metabolism in Purkinje cell dendritic arbors and motor coordination requires PRMT8 as a phospholipase2015

    • Author(s)
      un-Dal Kim, Junji Ishida, Koichiro Kako, Juri Hamada, Akiyoshi Fukamizu
    • Organizer
      第38回 日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠高血圧モデルマウスを用いた研究2015

    • Author(s)
      石田純治
    • Organizer
      第51回 高血圧関連疾患モデル学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府、豊中市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 血管内皮におけるタンパク質アルギニンメチル基転移酵素・PRMT1の機能解析2015

    • Author(s)
      石丸友博、石田純治、金 俊達、仲島由佳、橋本美涼、水上早瀬、杉山文博、八神健一、深水昭吉
    • Organizer
      第51回 高血圧関連疾患モデル学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府、豊中市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠高血圧マウスに対する複数の降圧剤投与による病態の改善効果2015

    • Author(s)
      権 哲源、石田純治、石丸友博、Haojun Xu、Baasanjav Altansarnai、水上早瀬、原加奈子、杉山文博、八神健一、深水昭吉
    • Organizer
      第51回 高血圧関連疾患モデル学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府、豊中市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠高血圧マウスへのL型カルシウムチャネルブロッカー投与による病態変化2015

    • Author(s)
      石田純治、Haojun Xu、石丸友博、権哲源、深水昭吉
    • Organizer
      第36回 日本妊娠高血圧学会
    • Place of Presentation
      北海道大学学術交流会館(北海道、札幌市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠高血圧マウス胎仔において降圧剤応答性を示すエタノールアミンの同定2015

    • Author(s)
      加香孝一郎、中村あゆみ、永島裕介、石田純治、深水昭吉
    • Organizer
      第36回 日本妊娠高血圧学会
    • Place of Presentation
      北海道大学学術交流会館(北海道、札幌市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒスタミンはヒスタミンH3受容体を介して心腎連関の病態に保護的に作用する2015

    • Author(s)
      野口 和之,石田 純治,石丸 友博,川崎 祥平,権 哲源,加香 孝一郎,山縣 邦弘,深水 昭吉
    • Organizer
      第6回 分子腎臓フォーラム
    • Place of Presentation
      グランフロント大阪(大阪府、大阪市)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 心筋特異的Protein Arginine Methyltransferase 1 (PRMT1) 欠損マウスは心不全を呈する2015

    • Author(s)
      村田 知弥、陸 偉哲、石田 純治、深水 昭吉
    • Organizer
      第6回 Molecular Cardiovascular Conference Ⅱ
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県、福岡市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管内皮タンパク質アルギニンメチル基転移酵素・PRMT1の機能解析2015

    • Author(s)
      石丸友博、石田純治、金俊達、橋本美涼、水上早瀬、杉山文博、八神健一、深水昭吉
    • Organizer
      第6回 Molecular Cardiovascular Conference Ⅱ
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県、福岡市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] レニン・アンジオテンシン系阻害による赤血球と血圧の異なる負の制御機構2015

    • Author(s)
      加藤 秀樹、石田 純治、松阪 泰二、深水 昭吉、南学 正臣
    • Organizer
      第58回 日本腎臓学会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] Interfnce of Epigenome and Metabolism2015

    • Author(s)
      Junji Ishida
    • Organizer
      第79回 日本循環器学会
    • Place of Presentation
      大阪国際会議場(大阪府、大阪市)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 妊娠高血圧マウスの乳腺発達に関する解析2015

    • Author(s)
      Baasanjav Altansarnai、村田知弥、石田純治、深水昭吉
    • Organizer
      第19回 アンジオテンシンカンファレンス
    • Place of Presentation
      都市センターホテル(東京都、千代田区)
    • Year and Date
      2015-02-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠高血圧マウスへの複数の降圧剤投与による病態改善効果の検討2014

    • Author(s)
      石丸友博、石田純治、橋本美涼、Baasanjav Altansarnai、Xu Haojun、水上早瀬、権哲源、杉山文博、八神健一、深水昭吉
    • Organizer
      第18回 日本心血管内分泌代謝学会
    • Place of Presentation
      横浜市開港記念会館(神奈川県、横浜市)
    • Year and Date
      2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠高血圧マウスモデルを用いた研究2014

    • Author(s)
      石田 純治
    • Organizer
      第37回 日本高血圧学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ヒト冠動脈における動脈硬化症関連因子Apelin-APJ系の新規発現パターンについて2014

    • Author(s)
      松林泰毅、橋本達夫、中森悠、鈴木将太、吉田伸一郎、藤田恵美、藤原亮、石黒裕章、戸谷義幸、岩崎圭右、志村岳、石田純治、深水昭吉、大橋健一、梅村敏
    • Organizer
      第37回 日本高血圧学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経特異的AT1受容体ノックアウトマウスの表現型解析2014

    • Author(s)
      徳留健、大谷健太郎、岸本一郎、石田純治、深水昭吉、宮里幹也、河野雄平、堀尾武史、河野雅和、寒川賢治
    • Organizer
      第37回 日本高血圧学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠高血圧マウスの乳腺発達に関する解析2014

    • Author(s)
      Altansarnai Baasanjav、村田知弥、石田純治、深水昭吉
    • Organizer
      第35回 日本妊娠高血圧学会
    • Place of Presentation
      新宿 京王プラザホテル(東京都、新宿区)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] EFFECT OF LACTATION ON POSTPARTUM CARDIAC FUNCTION OF PREGNANCY-ASSOCIATED HYPERTENSIVE MICE2014

    • Author(s)
      Junji Ishida, Kazuya Murata, Chiaki Saito, Juri Hamada, Fumihiro Sugiyama, Ken-ichi Yagami, and Akiyoshi Fukamizu
    • Organizer
      46th International Congress on Pathophysiology of Pregnancy
    • Place of Presentation
      新宿 京王プラザホテル(東京都、新宿区)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠高血圧マウスに対する複数の降圧剤投与による病態改善効果2014

    • Author(s)
      石丸友博、石田純治、中村匠子、橋本美涼、松倉頼、Baasanjav Altansarnai、Haojun Xu、水上早瀬、権哲源、杉山文博、八神健一、深水昭吉
    • Organizer
      5th Molecular cardiovascular conference II
    • Place of Presentation
      神戸ベイシェラトンホテル(兵庫県、神戸市)
    • Year and Date
      2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Ameliorative effect of L-type calcium channel blocker on the pathological conditions in mice with pregnancy-associated hypertension2014

    • Author(s)
      Haojun Xu, Junji Ishida, Tomohiro Ishimaru, Altansarnai Baasanjav, Misuzu Hashimoto, Kazuyuki Noguchi, and Akiyoshi Fukamizu
    • Organizer
      5th Molecular cardiovascular conference II
    • Place of Presentation
      神戸ベイシェラトンホテル(兵庫県、神戸市)
    • Year and Date
      2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠高血圧症候群病態に関与するアミノプロダクトの探索と同定2014

    • Author(s)
      加香孝一郎、永島裕介、石田純治、土屋敬広、嶋田崇史、深水昭吉
    • Organizer
      第9回 日本ケミカルバイオロジー学会
    • Place of Presentation
      大阪大学(大阪府、豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] A simple and low-invasive sepsis mouse model2014

    • Author(s)
      Yusuke Naito, Kento Yoshioka, Kensuke Tanaka, Hirofumi Matsunaga, Junji Ishida, Akiyoshi Fukamizu, Sadao Kimura, Koichiro Tatsumi, and Yoshitoshi Kasuya
    • Organizer
      American Thoracic Society 2014
    • Place of Presentation
      San Diego Convention Center, U.S.A.
    • Year and Date
      2014-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] A role of p38 Mitogen-Activated Protein Kinase in Emphysema Induced by Cigarette Smoke Solution and Lipopolysaccharide in Mice2014

    • Author(s)
      Hiroyuki Amano, Kazuya Murata, Hirofumi Matsunaga, Kensuke Tanaka, Takeshi Kobayashi, Junji Ishida, Akiyoshi Fukamizu, Fumihiro Sugiyama, Sadao Kimura, Koichiro Tatsumi, and Yoshitoshi Kasuya
    • Organizer
      American Thoracic Society 2014
    • Place of Presentation
      San Diego Convention Center, U.S.A.
    • Year and Date
      2014-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Combinatorial treatment with antihypertensive drugs prevents HELLP syndrome exacerbated by endothelial dysfunction in pregnant hypertensive mice.2014

    • Author(s)
      Junji Ishida, Tomohiro Ishimaru, Tanomu Matsukura, Shoko Nakamura, Haojun Xu, Altansarnai Baasanjav, Misuzu Hashimoto, Kazuya Murata, Katsumasa Nagano, Fumihiro Sugiyama, Ken-ichi Yagami, and Akiyoshi Fukamizu
    • Organizer
      International Vascular Biology Meeting 2014
    • Place of Presentation
      みやこメッセ(京都府、京都市)
    • Year and Date
      2014-04-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Vascular endothelial dysfunction in mice with pregnancy-associated hypertension2014

    • Author(s)
      Tomohiro Ishimaru, Junji Ishida, Tanomu Matsukura, Katsumasa Nagano, Fumihiro Sugiyama, Ken-ichi Yagami, and Akiyoshi Fukamizu
    • Organizer
      International Vascular Biology Meeting 2014
    • Place of Presentation
      みやこメッセ(京都府、京都市)
    • Year and Date
      2014-04-14
    • Related Report
      2014 Research-status Report
  • [Presentation] アペリン-APJ受容体系の血管内皮細胞障害時における血圧制御機構の解析2014

    • Author(s)
      石田純治、永野克将、海野まどか、松倉頼、深水昭吉
    • Organizer
      第51回 日本臨床分子医学会
    • Place of Presentation
      東京国際フォーラム(東京都、千代田区)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Research-status Report
  • [Presentation] ドキソルビシン誘導性の心毒性に対するアペリン-APJ系の役割2014

    • Author(s)
      濱田樹理、村田知弥、加香孝一郎、石田純治、深水昭吉
    • Organizer
      第51回 日本臨床分子医学会
    • Place of Presentation
      東京国際フォーラム(東京都、千代田区)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Lactation causes cardiac contractile dysfunction in mice with pregnancy-associated hypertension2014

    • Author(s)
      村田知弥、齊藤千明、石田純治、濱田樹理、杉山文博、 八神健一、深水昭吉
    • Organizer
      第51回 日本臨床分子医学会
    • Place of Presentation
      東京国際フォーラム(東京都、千代田区)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠高血圧マウスの病態発症・進展に対するAT1シグナル阻害効果の検討2014

    • Author(s)
      石丸友博、石田純治、中村匠子、橋本美涼、松倉頼、中村あゆみ、Baasanjav Altansarnai、國田智、杉山文博、八神健一、深水昭吉
    • Organizer
      第51回 日本臨床分子医学会
    • Place of Presentation
      東京国際フォーラム(東京都、千代田区)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Research-status Report
  • [Book] 実験医学別冊、マウス表現型解析スタンダード、循環器系の表現型解析2016

    • Author(s)
      石田純治、水上早瀬、権哲源、深水昭吉
    • Total Pages
      351
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report
  • [Remarks] 中枢神経系の発生や機能維持に重要な仕組みの一端を解明

    • URL

      http://www.tsukuba.ac.jp/attention-research/p201602041400.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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