| Project/Area Number |
26430091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kumamoto University |
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Principal Investigator |
Kuwata Takeo 熊本大学, エイズ学研究センター, 助教 (70346063)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUSHITA Shuzo 熊本大学, エイズ学研究センター, 教授 (00199788)
IGARASHI Tatsuhiko 京都大学, ウイルス研究所, 教授 (90467431)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | antibody / SIV / vaccine / HIV / 中和抗体 / アカゲザル / ワクチン |
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| Outline of Final Research Achievements |
SIV-infected macaques, which is an animal model of HIV infection, was used for analysis to develop antibody-inducing vaccines. Binding of potent anti-SIV neutralizing antibody B404 was not affected by point mutations on Env, and was suggested to require the structure of antigen-binding domain with negative charges. The biased induction of B404-class antibodies in macaques suggested the effect of host factors in antibody induction. Moreover, maturation of antibodies resulted in increase of neutralization activity against homologous virus, but did not associated with cross-neutralization activity against heterologous viruses
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