| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Dendritic Cell ImmunoReceptor(DCIR) is an inhibitory type of C-type lectin receptor and the functional defect of DCIR leads to disturbance of maintaining the homeostasis of the immune system. As Dcir-deficient mice spontaneously developed autoimmune-like diseases and were susceptible for some of experimental animal disease models, DCIR is involved in the pathogenesis of a sort of disease. Therefore, we evaluated the role of DCIR in a chronic inflammatory disorder. Moreover, we attempted to generate a tool of analyzing the function of an additional C-type lectin receptor.
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