The physiological functions of a C-type lectin receptor and the relation with diseases
Project/Area Number |
26430095
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
|
Research Institution | Tohoku Medical and Pharmaceutical University (2016) Tokyo University of Science (2014-2015) |
Principal Investigator |
KAIFU Tomonori 東北医科薬科大学, 医学部, 講師 (90343037)
|
Co-Investigator(Kenkyū-buntansha) |
岩倉 洋一郎 東京理科大学, 研究推進機構生命医科学研究所, 教授 (10089120)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | C型レクチン受容体 / DCIR / C型レクチン受容体 / リガンド |
Outline of Final Research Achievements |
Dendritic Cell ImmunoReceptor(DCIR) is an inhibitory type of C-type lectin receptor and the functional defect of DCIR leads to disturbance of maintaining the homeostasis of the immune system. As Dcir-deficient mice spontaneously developed autoimmune-like diseases and were susceptible for some of experimental animal disease models, DCIR is involved in the pathogenesis of a sort of disease. Therefore, we evaluated the role of DCIR in a chronic inflammatory disorder. Moreover, we attempted to generate a tool of analyzing the function of an additional C-type lectin receptor.
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Report
(4 results)
Research Products
(17 results)