| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
To study an association between Alzheimer's disease and herpes simplex virus infection, I considered in a pig herpesvirus (Aujeszky's disease virus) latent infection mouse model using the double transgenic mouse which crossbred PS2 and TG2576, the APP<NL-G-F> mouse which I introduced from the Institute of Physical and Chemical Research brain science synthesis research center, and senescence accelerating model mouse (SAM). It was all available for the condition of a disease model. Some difference was seen in β amyloid in the brain, the result including the cognitive function examination, however, it was revealed that various experiments were possible by choosing a system in total for a purpose. I am developing structure controlling latent virus reactivation and am a plan evaluating using such animal experiment system established this time now.
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