| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Progenies that had been exposed to in utero protein restriction exhibited alteration of behavioral phenotypes, gene expression patterns, and genomic methylation patterns in the brain. We generated knockout (KO) mouse differentially expressed or methylated in the brain of the progenies of protein restricted group that are thought to be involved in developmental disorders. Behavioral phenotypes of the KO mice were analyzed comprehensively. In the analyses, the KO mice exhibited altered behavioral phenotypes relative to wild type such as deficit fear and short term memories, decrease of pre-pulse inhibition, suppressed social interaction.
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