Exploration of genes responsible to abnormal behavior of adult mouse caused by malnutrition in fetal life
| Project/Area Number |
26430098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Furuse Tamio 国立研究開発法人理化学研究所, バイオリソースセンター, 開発研究員 (60392106)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 胎児期栄養 / マウス / 行動 / エピジェネティクス / 発達障害 / DOHaD / 胎児期低栄養 / マウスモデル |
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| Outline of Final Research Achievements |
Progenies that had been exposed to in utero protein restriction exhibited alteration of behavioral phenotypes, gene expression patterns, and genomic methylation patterns in the brain. We generated knockout (KO) mouse differentially expressed or methylated in the brain of the progenies of protein restricted group that are thought to be involved in developmental disorders. Behavioral phenotypes of the KO mice were analyzed comprehensively. In the analyses, the KO mice exhibited altered behavioral phenotypes relative to wild type such as deficit fear and short term memories, decrease of pre-pulse inhibition, suppressed social interaction.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny2017
Author(s)
Furuse T, Miyake K, Kohda T, Kaneda H, Hirasawa T, Yamada I, Kushida T, Kashimura M, Kobayashi K, Ishino F, Kubota T, Wakana S.
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Journal Title
Genes & Nutrition
Volume: 12
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Sirh7/Ldoc1 KO mice exhibit placental P4 overproduction and delayed parturition.2014
Author(s)
Naruse M., Ono R., Irie M., Nakamura K., Furuse T., Hino T., Oda K., Kashimura M., Yamada I., Wakana S., Yokoyama M., Ishino F., Kaneko-Ishino T.
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Journal Title
Development
Volume: 141
Pages: 4763-4771
Related Report
Peer Reviewed / Open Access
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