| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
It is well known that low quality oocytes increases with maternal age in humans. Low quality oocytes cause low pregnancies, or chromosome abnormalities of newborn infants. In this study, the quality of aged oocyte improved by non-micromanipulating approaches using mice. Abnormal revel (high revel) of histone deacetylase (HDAC) and aneuploidy were seen in MII oocytes after knock-down with histone deacetylase (HDAC) activity with "young oocytes" (9- to 12-week-old). These phenotypes were similar to aged oocytes, so HDAC activity might be involved to aged oocyte abnormalities. In superovulation methods of aged female mice (8- to 15-month-old), using injection of anti-inhibin serum (AIS) which works with endogenous FSH instead of eCG which works as exogenous FSH was increased the number of ovulated oocytes and decreased abnormal oocytes.
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