| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
High matrix stiffness triggers cancer progression; however, detailed molecular mechanisms of this phenomenon are not clear. Hence, it is necessary to identify transcription factors that contribute to malignant alteration in response to increasing substrate stiffness. In this study, we found that activating transcription factor 5 (ATF5) enhances the invasiveness of cancer cells. In addition, we revealed that ATF5 regulates the expression of genes encoding integrins, which are important for substrate stiffness sensing. Based on these observations, ATF5 possibly drives cancer progression due to stiff matrix. We also examined ATF5 localization on substrates with different rigidity. Matrix rigidity affects ATF5 transport to the nucleus.
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