Stiff Substrates Enhances ATF5-Signaling-Mediated Invasive Ability in Cancer Cells
Project/Area Number |
26430104
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor biology
|
Research Institution | Hokkaido University |
Principal Investigator |
HAGA HISASHI 北海道大学, 先端生命科学研究院, 教授 (00292045)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | がん細胞 / 浸潤 / メカノセンス / 炎症性反応 / 転写調節因 / 転写調節因子 |
Outline of Final Research Achievements |
High matrix stiffness triggers cancer progression; however, detailed molecular mechanisms of this phenomenon are not clear. Hence, it is necessary to identify transcription factors that contribute to malignant alteration in response to increasing substrate stiffness. In this study, we found that activating transcription factor 5 (ATF5) enhances the invasiveness of cancer cells. In addition, we revealed that ATF5 regulates the expression of genes encoding integrins, which are important for substrate stiffness sensing. Based on these observations, ATF5 possibly drives cancer progression due to stiff matrix. We also examined ATF5 localization on substrates with different rigidity. Matrix rigidity affects ATF5 transport to the nucleus.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Conformational Plasticity of JRAB/MICAL-L2 Provides 'Law and Order'2016
Author(s)
A. Sakane, S. Yoshizawa, M. Nishimura, Y. Tsuchiya, N. Matsushita, K. Miyake, K. Horikawa, I. Imoto, C. Mizuguchi, H. Saito, T. Ueno, S. Matsushita, H. Haga, S. Deguchi, K. Mizuguchi, H.
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Journal Title
Molecular Biology of the Cell
Volume: 27
Issue: 20
Pages: 3095-3108
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers2016
Author(s)
T.Yamada, M. Tsuda, T. Wagatsuma, Y. Fujioka, M. Fujioka, A. O. Satoh, K. Horiuchi, S. Nishide, A. Nanbo, Y. Totsuka, H. Haga, S. Tanaka, M. Shindoh, and Y. Ohba
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 23545-23545
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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