Research Project
Grant-in-Aid for Scientific Research (C)
Chromosome translocations induced by ionizing radiation and chemotherapeutic agents, has been shown to lead to malignant transformation. However, the mechanism of chromosome translocations is still unclear. Chromosome translocations involving the MLL gene on 11q23 are the most frequent chromosome abnormalities in secondary leukemias associated with chemotherapy employing etoposide. Dysfunction of ATM, a DNA damage signaling regulator, increases the incidence of 11q23 chromosome translocations. We showed that ATM deficiency results in the excessive binding of the DNA recombinase RAD51 at the translocation breakpoint cluster region (BCR) of MLL gene after etoposide exposure. In this study, we showed that a phosphorylated subunit of INO80 complex by ATM, plays an important role in the appropriate regulation of INO80 and RAD51 binding to the BCR of MLL gene and prevention of 11q23 chromosome translocations after etoposide treatment.
All 2017 2016 2015 2014
All Journal Article (7 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 7 results, Open Access: 7 results, Acknowledgement Compliant: 5 results) Presentation (14 results) (of which Int'l Joint Research: 1 results)
Cancer Sci.
Volume: 107 Issue: 4 Pages: 444-451
10.1111/cas.12899
Genes Cells.
Volume: 20 Issue: 9 Pages: 681-94
10.1111/gtc.12262
FASEB J.
Volume: in press Issue: 6 Pages: 2514-25
10.1096/fj.14-265546
Nature Immunol.
Volume: 15 Issue: 12 Pages: 1171-1180
10.1038/ni.3024
Int J Radiat Oncol Biol Phys.
Volume: 89 Pages: 736-44
Oxid. Med. Cell. Longev.
Volume: 2014 Pages: 757901-757901
10.1155/2014/757901
Scientific Rep.
Volume: 4 Issue: 1 Pages: 4863-4863
10.1038/srep04863
