| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
We analyzed molecular mechanisms of the Sialyl-Tn (sTn) antigen-induced alterations encompassing the reduced cell proliferation, the acquisition of anti-oxidative stress and anti-apoptosis under hypoxic conditions which are based on the tumor adaptation to dramatically changing microenvironments, and then we found that sTn antigen reduces cell cycle and induces antioxidant enzymes that confers anti-apoptotic functions on tumor cells under hypoxic conditions. These sTn antigen-induced cellular functions are important for survival and metastasis of tumor cells.
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