Analyses of molecular mechanism of the glycan-dependent adaptation of tumor cells to tumor microenvironments
| Project/Area Number |
26430118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Ohtsubo Kazuaki 熊本大学, 大学院生命科学研究部(保), 教授 (30525457)
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| Co-Investigator(Renkei-kenkyūsha) |
KOREKANE Hiroaki 独立行政法人理化学研究所, 疾患糖鎖研究チーム, 研究員 (50421912)
NAKAJIMA Kazuki 独立行政法人理化学研究所, 新液播く機能研究チーム, 研究員 (10442998)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 糖鎖修飾 / がん糖鎖 / シアリルTn抗原 / 転移 / 浸潤 / 低酸素 / 糖鎖 / sTn抗原 / がん転移 / がん微小環境 / 糖転移酵素 / 抗アポトーシス |
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| Outline of Final Research Achievements |
We analyzed molecular mechanisms of the Sialyl-Tn (sTn) antigen-induced alterations encompassing the reduced cell proliferation, the acquisition of anti-oxidative stress and anti-apoptosis under hypoxic conditions which are based on the tumor adaptation to dramatically changing microenvironments, and then we found that sTn antigen reduces cell cycle and induces antioxidant enzymes that confers anti-apoptotic functions on tumor cells under hypoxic conditions. These sTn antigen-induced cellular functions are important for survival and metastasis of tumor cells.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.2017
Author(s)
Ishii T, Angata T, Wan ES, Cho MH, Motegi T, Gao C, Ohtsubo K, Kitazume S, Gemma A, Pare PD, Lomas DA, Silverman EK, Taniguchi N, Kida K
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Journal Title
Respirology
Volume: 22
Pages: 684-690
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models2017
Author(s)
Gao C, Fujinawa R, Yoshida T, Ueno M, Ota F, Kizuka Y, Hirayama T, Korekane H, Kitazume S, Maeno T, Ohtsubo K, Yoshida K, Yamaguchi Y, Lepenies B, Aretz J, Rademacher C, Kabata H, Hegab AE, Seeberger PH, Betsuyaku T, Kida K, Taniguchi N.
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Journal Title
American Journal of Physiology-Lung Cellular and Molecular Physiology
Volume: 312
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating multiple cellular signaling.2015
Author(s)
Yuqin Wang, Tomohiko Fukuda, Tomoya Isaji, Jishun Lu, Sanghun Im, Qinglei Hang, Wei Gu, Sicong Hou, Kazuaki Ohtsubo, Jianguo Gu
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Journal Title
FASEB J.
Volume: 29
Pages: 3217-27
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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