| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Myeloid-derived suppressor cells (MDSC) are known to inhibit immune responses against tumors or in chronic infections, although their developmental mechanisms have remained unclear. In this study, we noticed that MDSC-like cells are spontaneously accumulated in alymphoplasia, the mice bearing a mutation in NF-kB-inducing kinase. We analyzed the phenotypes and function of these cells comparing them with those of tumor-induced MDSCs, and following results were obtained. (1) MDSC-like cells in aly mice were divided into three populations in terms of their expression of Ly6C and Ly6G. (2) All of these three population exhibited the ability to suppress T cell proliferation at similar level as tumor-induced MDSCs. (3) These populations were not observed in aly mice lacking mature lymphocytes. These results collectively indicated that lack of functional NIK may lead to the development of MDSC, and that the development of (subsets of) MDSC may be dependent on the function of lymphocytes.
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