| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We investigated tumor suppressive effect of indole-3-carbinol (I3C), which is the bioactive component contained in cruciferous vegetables, by studying the mice fed with the diet containing I3C or by examining culture cells treated with I3C. The former resulted in suppression of innate immunity-related genes in the intestine, the latter showed growth inhibitory effect. In addition, it was shown that inflammatory cytokine promoted cell proliferation in the primary culture system of intestinal epithelia. These results suggest that I3C suppresses cell proliferation by regulating inflammatory responses through its receptor.
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