Roles of DNA damage and repair pathway in gastric carcinogenesis after eradication of Helicobacter pylori
| Project/Area Number |
26430132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Toyoda Takeshi 国立医薬品食品衛生研究所, 病理部, 室長 (50443453)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胃がん / 除菌 / 慢性胃炎 / ヘリコバクター・ピロリ / スナネズミ / DNA修復 |
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| Outline of Final Research Achievements |
In this study, we investigated the possible mechanisms in gastric carcinogenesis after eradication of Helicobacter pylori using a Mongolian gerbil model. The incidences of gastric adenocarcinoma in MNU-treated gerbils at week 52 were 0% in early eradication, 14% in late eradication, and 71% in non-eradication group. Although the degree of chronic gastritis was attenuated, inflammatory findings were still observed in the gastric mucosa after eradication. mRNA expression of Il-1β and Tnf-α in the antrum and corpus rapidly reduced by eradication, while Il-6 and Ifn-γ expression tended to decrease gradually. At week 52, Il-6 expressions in MNU-treated and eradicated groups were higher than those in MNU-untreated and eradicated groups. These results suggest that chronic gastritis with expression of inflammatory cytokines such as Il-6 can persist for a long period even after eradication and may be involved in the development of stomach cancer after eradication.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Toxic effects of 4-methylthio-3-butenyl isothiocyanate (Raphasatin) in the rat urinary bladder without genotoxicity2017
Author(s)
Suzuki I, Cho YM, Hirata T, Toyoda T, Akagi J, Nakamura Y, Sasaki A, Nakamura T, Okamoto S, Shirota K, Suetome N, Nishikawa A, Ogawa K
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Journal Title
J Appl Toxicol
Volume: 37
Issue: 4
Pages: 485-494
DOI
Related Report
Peer Reviewed
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[Journal Article] 4-Methylthio-3-butenyl isothiocyanate (Raphasatin) exerts chemopreventive effects against esophageal carcinogenesis in rats2016
Author(s)
Suzuki I, Cho YM, Hirata T, Toyoda T, Akagi J, Nakamura Y, Park EY, Sasaki A, Nakamura T, Okamoto S, Shirota K, Suetome N, Nishikawa A, Ogawa K
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Journal Title
J Toxicol Pathol
Volume: 29
Issue: 4
Pages: 237-246
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4 week comprehensive toxicity study using F344 gpt delta rats2014
Author(s)
Onami S, Cho YM, Toyoda T, Horibata K, Ishii Y, Umemura T, Honma M, Nohmi T, Nishikawa A, Ogawa K
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Journal Title
Mutagenesis
Volume: 29
Issue: 4
Pages: 295-302
DOI
Related Report
Peer Reviewed
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