| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we investigated the possible mechanisms in gastric carcinogenesis after eradication of Helicobacter pylori using a Mongolian gerbil model. The incidences of gastric adenocarcinoma in MNU-treated gerbils at week 52 were 0% in early eradication, 14% in late eradication, and 71% in non-eradication group. Although the degree of chronic gastritis was attenuated, inflammatory findings were still observed in the gastric mucosa after eradication. mRNA expression of Il-1β and Tnf-α in the antrum and corpus rapidly reduced by eradication, while Il-6 and Ifn-γ expression tended to decrease gradually. At week 52, Il-6 expressions in MNU-treated and eradicated groups were higher than those in MNU-untreated and eradicated groups. These results suggest that chronic gastritis with expression of inflammatory cytokines such as Il-6 can persist for a long period even after eradication and may be involved in the development of stomach cancer after eradication.
|
