| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We found that ICAM-1 protein is strongly and synergistically induced in ovarian clear cell carcinoma (CCC) cells in response to serum starvation and hypoxia (SSH). We also found that ICAM1 contributes to CCC cell survival and CCC tumor growth by inhibiting apoptosis process. We identified long chain fatty acids as a major class of lipids that is associated with albumin, a serum factor responsible for synergistic gene activation under SSH. Furthermore, we comprehensively investigated how mRNA level and phosphorylation level of proteins in CCC cells can be altered in response to ICAM1 expression. We found that multiple proteins such as filaggrin can be phosphorylated in a ICAM1-dependent manner in CCC cells exposed to SSH condition. These results indicate that phosphorylation of these proteins may play crucial roles in anti-apoptotic function of ICAM1 in CCC cells under SSH condition.
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