| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Cancer is a disease of genes, and also is a disease strongly influenced from the environment. In recent years, obesity has formed an environment called mild chronic inflammation, and the mechanism by which cancer develops from it has drawn attention.
Therefore, in this study, we verified high nutrient intake in cultured cells or in mice brought into obesity conditions can evoke epigenomic changes such as DNA methylation occur at such frequencies as to explain the carcinogenic processes.
As a result, it was revealed that the DNA methylation state could be changed depending on the nutrient condition by long-term cultivation in the sugar-rich medium / lipid-rich medium in the experiment on the cultured cell level. We continue to conduct similar experiments and measurements also at the animal individual level.
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