Tailor-made medicine approach for control of cancer heterogeneity and drug resistance
Project/Area Number |
26430140
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor diagnostics
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Research Institution | University of Tsukuba |
Principal Investigator |
Nagumo Yoko 筑波大学, 生命環境系, 助教 (70373339)
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Project Period (FY) |
2014-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 薬剤感受性変動 / オーダーメード治療 / オーダーメイド治療 |
Outline of Final Research Achievements |
Cancer may recur due to the development of drug resistance, even if the regression is seen in the first drug therapy. In this study, we aimed to develop a strategy to derive a tailor-made medicine that maintains sensitivity for a longer time by analyzing the modulation that various anticancer agents give to ovarian cancer cells. As a result of creating a drug resistant cell library, we found a tendency for cells and drugs that are easy to obtain resistance, and found a combination that could obtain a synergistic effect when used in combination with resistant drugs, or one that was more sensitive. Furthermore, from the microarray analysis, when an inhibitor of a certain gene product was used, a resistance reducing effect was observed. From the above, selection of drugs to be used for resistant cancer cells, that is, information on tailor-made medicine was obtained.
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Academic Significance and Societal Importance of the Research Achievements |
不均一性が特に高い卵巣がんを対象に、種々の抗がん剤が、個々のがん細胞に与える変動を解析することで、薬剤耐性を得やすい細胞・薬剤や、悪性度に関する情報を得た。次に、耐性化した場合に次に処理するべき薬剤の選出、感受性にシフトさせる投薬法についての情報が得られた。以上のストラテジーは、実際のがんに応用することで、感受性を維持し悪性度の低い状態に長く留めるためのオーダーメード投薬法に寄与するものである。
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Report
(6 results)
Research Products
(27 results)
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[Journal Article] Eudistomin C, an antitumor and antiviral natural product, targets 40S ribosome and inhibits protein translation2016
Author(s)
Ota Y, Chinen T, Yoshida K, Kudo S, Nagumo Y, Shiwa Y, Yamada R, Umihara H, Iwasaki K, Masumoto H, Yokoshima S, Yoshikawa H, Fukuyama T, Kobayashi J, and Usui T.
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Journal Title
ChemBioChem.
Volume: 17
Issue: 17
Pages: 1616-1620
DOI
Related Report
Peer Reviewed
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[Journal Article] Vicenistatin induces early endosome-derived vacuole formation in mammalian cells2016
Author(s)
Yuko Nishiyama, Tomohiro Ohmichi, Sayaka Kazami, Hiroki Iwasaki, Kousuke Mano, Yoko Nagumo, Fumitaka Kudo, Sosaku Ichikawa, Yoshiharu Iwabuchi, Naoki Kanoh, Tadashi Eguchi, Hiroyuki Osada & Takeo Usui
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: accepted
Issue: 5
Pages: 902-910
DOI
Related Report
Peer Reviewed
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[Journal Article] Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B2015
Author(s)
Shun-ichiro Uesugi, Tsubasa Watanabe, Takamichi Imaizumi, Yu Ota, Keisuke Yoshida, Haruna Ebisu, Takumi Chinen, Yoko Nagumo, Masatoshi Shibuya, Naoki Kanoh, Takeo Usui, and Yoshiharu Iwabuchi
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Journal Title
The Journal of Organic Chemistry
Volume: 80(24)
Issue: 24
Pages: 12333-50
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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