Genomic instability of ALK fusion positive lung adenocarcinoma
| Project/Area Number |
26430149
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Tumor diagnostics
|
|---|
| Research Institution | Japanese Foundation for Cancer Research |
|---|
Principal Investigator |
NINOMIYA HIRONORI 公益財団法人がん研究会, がん研究所 病理部, 研究員 (20462228)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
石川 雄一 公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 肺腺癌 / ALK融合遺伝子 / ゲノム不安定性 / クロモトリプシス / chromothripsis / 遺伝子増幅 / EML4-ALK陽性 / 腺扁平上皮癌 / EML4-ALK / CGHアレイ |
|---|
| Outline of Final Research Achievements |
We analyzed surgically resected pulmonary adenocarcinomas with Copy number analyzer for GeneChip (CNAG). The result revealed that frequent copy number change occurred on the short arm of chromosome 2 among ALK fusion positive cases. Same genomic alteration patter was detected in 10 cases among 35 (28.5%). On the other hand, no case showed similar copy number change among ALK fusion negative cases. The result revealed that genomic fragmentation and reconstruction is a notable mechanism of ALK fusion gene formation leading to carcinogenesis.
|
Report
(5 results)
Research Products
(7 results)
-
-
-
-
-
[Presentation] ALK肺腺癌において高悪性度組織亜型Solid，Micropapは予後因子となるか2014
Author(s)
松浦陽介, 元井紀子, 二宮浩範, 山崎宏嗣, 平井慶充, 後藤英典, 森彰平, 鮫島譲司, 中尾将之, 上原浩文, 文敏景, 中川健, 石川雄一, 奥村栄
Organizer
第55回日本肺癌学会
Place of Presentation
京都
Year and Date
2014-11-15 – 2014-11-16
Related Report
-
-
