• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Genomic instability of ALK fusion positive lung adenocarcinoma

Research Project

Project/Area Number 26430149
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor diagnostics
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

NINOMIYA HIRONORI  公益財団法人がん研究会, がん研究所 病理部, 研究員 (20462228)

Co-Investigator(Kenkyū-buntansha) 石川 雄一  公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肺腺癌 / ALK融合遺伝子 / ゲノム不安定性 / クロモトリプシス / chromothripsis / 遺伝子増幅 / EML4-ALK陽性 / 腺扁平上皮癌 / EML4-ALK / CGHアレイ
Outline of Final Research Achievements

We analyzed surgically resected pulmonary adenocarcinomas with Copy number analyzer for GeneChip (CNAG). The result revealed that frequent copy number change occurred on the short arm of chromosome 2 among ALK fusion positive cases. Same genomic alteration patter was detected in 10 cases among 35 (28.5%). On the other hand, no case showed similar copy number change among ALK fusion negative cases. The result revealed that genomic fragmentation and reconstruction is a notable mechanism of ALK fusion gene formation leading to carcinogenesis.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2018 2016 2015 2014

All Presentation (6 results) (of which Int'l Joint Research: 1 results) Funded Workshop (1 results)

  • [Presentation] 肺癌のゲノムワイド解析2018

    • Author(s)
      稲村健太郎
    • Organizer
      日本病理学会総会 札幌 6月21日-6月23日
    • Related Report
      2017 Annual Research Report
  • [Presentation] EML4-ALK陽性腺扁平上皮癌の2例2016

    • Author(s)
      二宮 浩範
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡国際会議場、福岡サンパレス、福岡国際センター
    • Year and Date
      2016-12-19
    • Related Report
      2016 Research-status Report
  • [Presentation] EML4-ALK陽性扁平上皮癌成分を有する2症例の分子生物学的解析2016

    • Author(s)
      二宮 浩範
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Unique pattern of copy number changes including chromothripsis in pulmonary adenocarcinoma with EML4-ALK fusion2015

    • Author(s)
      Hironori Ninomiya
    • Organizer
      AACR annual meeting 2015
    • Place of Presentation
      Pennsylvania Convention Center Philadelphia, Pennsylvania.
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ALK肺腺癌において高悪性度組織亜型Solid,Micropapは予後因子となるか2014

    • Author(s)
      松浦陽介, 元井紀子, 二宮浩範, 山崎宏嗣, 平井慶充, 後藤英典, 森彰平, 鮫島譲司, 中尾将之, 上原浩文, 文敏景, 中川健, 石川雄一, 奥村栄
    • Organizer
      第55回日本肺癌学会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Lung adenocarcinoma with unique pathological features2014

    • Author(s)
      Hironori Ninomiya, Yuichi Ishikawa
    • Organizer
      IAP日台スライドカンファレンス
    • Place of Presentation
      台湾 台北
    • Year and Date
      2014-10-25 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Funded Workshop] AACR annual meeting2015

    • Place of Presentation
      Pennsylvania Convention Center
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi