Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
We have attempted to identify a novel glycan tumor marker by comparing the serum O-glycan profiles from healthy controls with those of cancer patients. We identified 3 marker candidates. The precise oligosaccharide structures of these candidates was clarified. To quantify these glycans, we developed the selected reaction monitoring (SRM) assay, which used a stable isotope-labeled glycan as internal standard with a high level of sensitivity and accuracy. Verification study of one of the candidate was then performed by SRM analyses.
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