| Project/Area Number |
26430154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Tohoku University |
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Principal Investigator |
Ishii Keiko 東北大学, 医学系研究科, 准教授 (00291253)
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| Co-Investigator(Kenkyū-buntansha) |
高見 誠一 東北大学, 多元物質科学研究所, 准教授 (40311550)
阿部 敬悦 東北大学, 農学研究科, 教授 (50312624)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Kazuyoshi 東北大学, 大学院医学系研究科, 教授 (10253973)
OSANAI Makoto 東北大学, 大学院医学系研究科, 准教授 (90286419)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ステルス化 / 酸化鉄ナノ粒子 / MRIによる診断 / 温熱療法 / ガン組織指向性 / scFv / がん組織指向性 / ナノ粒子 / 酸化鉄 / ステルス性 / 網内系捕捉回避 / MRI |
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| Outline of Final Research Achievements |
This study aimed to develop magnetic iron-oxide nanoparticles with novel properties for the imaging and thermal therapies of cancer in deep tissues and intractable cancer. It has been a problem that intravenously injected nanoparticles are mostly trapped by the reticuloendothelial system in liver and spleen before they reach target cancer cells. We approached this issue by coating the iron-oxide particles with RolA, a surface hydrophobin of Aspergillus oryzae. RolA-coated iron-oxide nanoparticles were less recognized by macrophages, suggesting they are endowed with stealth property. We further aimed to add an active targeting property to the iron-oxide nanoparticles and produced a single-chain fragment variable (scFv) containing variable regions of anti-HER2 antibody pertuzumab.
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