Grant-in-Aid for Scientific Research (C)
Although elimination regulatory T-cell（Treg）by anti-CCR4 antibody was clearly observed, and the reactivation of immunity with the elimination of Tregs was partially clarified in in vitro experiment, the expected results could not be achieved because human Tregs were not almost infiltrated into cancer tissue generated in mouse. However, it is expected that the spread to mouse model for human cancer immunotherapy using immune checkpoint inhibitors etc. because human T-cells were remarkably infiltrated into the tissue and the cancer necrosis was observed. And, CCR4+Treg subset analysis in human cancer tissues was performed. it was observed that infiltration of CCR4+Treg subset is related with pathological stage and recurrence which suggest significance of cancer therapy targeting CCR4.
Jpn J Clin Oncol.
Clinical Cancer Research
Clin Cancer Res.
Volume: 21 (12)
The Frontiers in Life Sciences. 生命科学から創薬へのイノベーション
Attribution of KAKENHI