Development of next generation transdermal vaccine for cancer treatment

• Project/Area Number: 26430176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Kurume University
• Principal Investigator: YAMADA Akira 久留米大学, 先端癌治療研究センター, 教授 (50158177)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: がん / 免疫療法 / がんワクチン / アジュバント / 腫瘍 / 経皮免疫 / ペプチドワクチン

Outline of Final Research Achievements

Freund’s incomplete adjuvant, one of the most popularly used adjuvant for cancer vaccines, has several adverse effects such as long term retention and an induction of inflammation at the injection site. We attempted to develop a next generation of transdermal vaccine for cancer treatment with no or low such adverse effects. We found that glycyrrhizin augmented vaccine-induced immune response with transdermal adjuvant, and the augmenting effect of glycyrrhizin was also observed in other synthetic HMGB1 inhibitors. Thus the effects are common to the HMGB1 inhibitors. In a therapeutic vaccine model, glycyrrhizin inhibited the growth of transplanted tumors. These findings might be valuable for further development of transdermal vaccines.

Research Products

• [Journal Article] Feasibility Study of Personalized Peptide Vaccination for Advanced Small Cell Lung Cancer. (2017)
  • Author(s): Sakamoto S, Yamada T, Terazaki Y, Yoshiyama K, Sugawara S, Takamori S, Matsueda S, Shichijo S, Yamada A, Noguchi M, Itoh K, Hattori N, Kohno N, Sasada T.
  • Journal Title: Clin Lung Cancer. Volume: 印刷中 Issue: 6 Pages: e385-e394
  • DOI: 10.1016/j.cllc.2017.03.011
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Impact of Tumor-Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma. (2017)
  • Author(s): Sudo T, Nishida R, Kawahara A, Saisho K, Mimori K, Yamada A, Mizoguchi A, Kadoya K, Matono S, Mori N, Tanaka T, Akagi Y.
  • Journal Title: Ann Surg Oncol. Volume: in press Issue: 12 Pages: 3763-3770
  • DOI: 10.1245/s10434-017-5796-4
  • Peer Reviewed / Open Access
• [Journal Article] Plasma Levels of High-Mobility Group Box 1 during Peptide Vaccination in Patients with Recurrent Ovarian Cancer. (2017)
  • Author(s): Waki K, Kawano K, Tsuda N, Ushijima K, Itoh K, Yamada A.
  • Journal Title: Journal of Immunology Research Volume: 2017 Pages: 1423683-1423683
  • DOI: 10.1155/2017/1423683
  • Peer Reviewed / Open Access
• [Journal Article] A randomized phase II trial of personalized peptide vaccine with low dose cyclophosphamide in biliary tract cancer. (2017)
  • Author(s): Shirahama T, Muroya D, Matsueda S, Yamada A, Shichijo S, Naito M, Yamashita T, Sakamoto S, Okuda K, Itoh K, Sasada T, Yutani S.
  • Journal Title: Cancer Sci. Volume: 印刷中 Issue: 5 Pages: 838-845
  • DOI: 10.1111/cas.13193
  • Peer Reviewed / Open Access
• [Journal Article] Immunological evaluation of peptide vaccination for cancer patients with the HLA -A11+ or -A33+ allele. (2017)
  • Author(s): Sakamoto S, Matsueda S, Takamori S, Toh U, Noguchi M, Yutani S, Yamada A, Shichijo S, Yamada T, Suekane S, Kawano K, Naitou M, Sasada T, Hattori N, Kohno N, Itoh K.
  • Journal Title: Cancer Sci. Volume: 印刷中 Issue: 4 Pages: 598-603
  • DOI: 10.1111/cas.13189
  • Peer Reviewed / Open Access
• [Journal Article] Immunological evaluation of personalized peptide vaccination for patients with histologically unfavorable carcinoma of unknown primary site. (2016)
  • Author(s): Sakamoto S, Yutani S, Shichijo S, Morita M, Yamada A, Itoh K, Noguchi M.
  • Journal Title: Cancer Immunol Immunother. Volume: 65(10) Issue: 10 Pages: 1223-1231
  • DOI: 10.1007/s00262-016-1887-5
  • Peer Reviewed / Open Access
• [Journal Article] Blockade of High Mobility Group Box 1 (HMGB1) augments anti-tumor T-cell response induced by peptide vaccination as a co-adjuvant. (2016)
  • Author(s): Waki K, Yamada A.
  • Journal Title: Cancer Sci. Volume: 107(12) Issue: 12 Pages: 1721-1729
  • DOI: 10.1111/cas.13084
  • Peer Reviewed / Open Access
• [Journal Article] Personalized Kampo Medicine Facilitated Both Cytotoxic T Lymphocyte Response and Clinical Benefits Induced by Personalized Peptide Vaccination for Advanced Esophageal Cancer. (2016)
  • Author(s): Muroya D, Yutani S, Shichijo S, Yamada A, Sakamoto S, Naito M, Okuda K, Morita M, Yamaguchi R, Itoh K.
  • Journal Title: Evid Based Complement Alternat Med. Volume: 2016 Pages: 5929525-5929525
  • Peer Reviewed / Open Access
• [Journal Article] Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients. (2016)
  • Author(s): Iwasa S, Yamada Y, Heike Y, Shoji H, Honma Y, Komatsu N, Matsueda S, Yamada A, Morita M, Yamaguchi R, Tanaka N, Kawahara A, Kage M, Shichijo S, Sasada T, Itoh K.
  • Journal Title: Cancer Sci. Volume: 印刷中 Issue: 5 Pages: 590-600
  • DOI: 10.1111/cas.12919
  • Peer Reviewed / Open Access
• [Journal Article] トリプルネガティブ乳がんに対する混合ペプチドワクチン（KRM-19）療法の臨床的検討 (2016)
  • Author(s): 唐 宇飛、朔 周子、岡部 実奈、岩熊 伸高、君付 優子、赤司 桃子、淡河 恵津世、山田 亮、七條 茂樹、伊東 恭悟、赤木 由人
  • Journal Title: 癌と化学療法 Volume: 第43巻 第10号 Pages: 1249-1251
  • Peer Reviewed
• [Journal Article] 急速に発展する免疫療法：がんワクチンの新展開 (2016)
  • Author(s): 和氣 加容子、山田 亮
  • Journal Title: BIO INDUSTRY Volume: 第33巻 第5号 Pages: 11-18
• [Journal Article] Randomized phase II study of docetaxel plus personalized peptide vaccination versus docetaxel plus placebo for patients with previously treated advanced wild type EGFR non-small-cell lung cancer. (2016)
  • Author(s): Takayama K, Sugawara S, Saijo Y, Maemondo M, Sato A, Takamori S, Harada T, Sasada T, Kakuma T, Kishimoto J, Yamada A, Noguchi M, Itoh K, Nakanishi Y.
  • Journal Title: Immunol Res. Volume: In press
  • Peer Reviewed
• [Journal Article] Identification and gene of new major allergen Cha o 3 from Chamaecyparis obtusa (Japanes Cypress) pollen. (2016)
  • Author(s): Osada T, Harada T, Asaka N, Kino K, Sasaki E, Okano M, Yamada A, Utsugi T.
  • Journal Title: J allergy clin immunol. Volume: In press
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphisms of the Haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination. (2016)
  • Author(s): Waki K, Yamada T, Yoshiyama K, Terazaki Y, Sakamoto S, Sugawara S, Takamori S, Itoh K, Yamada A.
  • Journal Title: Oncol Letter 2016 Volume: in press
  • Peer Reviewed
• [Journal Article] A randomized phase II clinical trial of personalized peptide vaccination with metronomic low-dose cyclophosphamide in patients with metastatic castration-resistant prostate cancer. (2016)
  • Author(s): Noguchi M, Moriya F, Koga N, Matsueda S, Sasada T, Yamada A, Kakuma T, Itoh K.
  • Journal Title: Cancer Immunol Immunother. Volume: 65 Issue: 2 Pages: 151-60
  • DOI: 10.1007/s00262-015-1781-6
  • Peer Reviewed
• [Journal Article] A Phase 2 Randomized Controlled Trial of Personalized Peptide Vaccine Immunotherapy with Low-dose Dexamethasone Versus Dexamethasone Alone in Chemotherapy-naive Castration-resistant Prostate Cancer. (2016)
  • Author(s): Yoshimura K, Minami T, Nozawa M, Kimura T, Egawa S, Fujimoto H, Yamada A, Itoh K, Uemura H.
  • Journal Title: Eur Urol Volume: 70(1) Issue: 1 Pages: 35-41
  • DOI: 10.1016/j.eururo.2015.12.050
  • Peer Reviewed / Open Access
• [Journal Article] Identification of novel Lck-derived T helper epitope long peptides applicable for HLA-A2(+) cancer patients as cancer vaccine. (2015)
  • Author(s): Matsueda S, Shichijo S, Nagata S, Seki C, Yamada A, Noguchi M, Itoh K.
  • Journal Title: Cancer Sci. Volume: 106(11) Issue: 11 Pages: 1493-8
  • DOI: 10.1111/cas.12805
  • Peer Reviewed / Open Access
• [Journal Article] Immunological evaluation of peptide vaccination for cancer patients with the HLA-A26 allele. (2015)
  • Author(s): Sakamoto S, Matsueda S, Takamori S, Toh U, Noguchi M, Yutani S, Yamada A, Shichijo S, Yamada T, Suekane S, Kawano K, Sasada T, Hattori N, Kohno N, Itoh K.
  • Journal Title: Cancer Sci. Volume: 106 Issue: 10 Pages: 1257-1263
  • DOI: 10.1111/cas.12757
  • NAID: 120006799352
  • Peer Reviewed / Open Access
• [Journal Article] Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advanced Hepatocellular Carcinoma Patients. (2015)
  • Author(s): Yutani S, Ueshima K, Abe K, Ishiguro A, Eguchi J, Matsueda S, Komatsu N, Shichijo S, Yamada A, Itoh K, Sasada T, Kudo M, Noguchi M.
  • Journal Title: J Immunol Res. Volume: 2015 Pages: 473909-473909
  • DOI: 10.1155/2015/473909
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination. (2015)
  • Author(s): Sakamoto S, Yoshitomi M, Yutani S, Terazaki Y, Yoshiyama K, Ioji T, Matsueda S, Yamada A, Takamori S, Itoh K, Hattori N, Kohno N, Sasada T.
  • Journal Title: Hum Vaccin Immunother. Volume: 11 Issue: 12 Pages: 2784-9
  • DOI: 10.1080/21645515.2015.1075107
  • NAID: 120006799351
  • Peer Reviewed / Open Access
• [Journal Article] Personalized peptide vaccination for cervical cancer patients who have received prior platinum-based chemotherapy. (2015)
  • Author(s): Kawano K, Tsuda N, Waki K, Matsueda S, Hata Y, Ushijima K, Itoh K, Yamada A, Kamura T.
  • Journal Title: Cancer Sci. Volume: 106(9) Issue: 9 Pages: 1111-7
  • DOI: 10.1111/cas.12729
  • Peer Reviewed / Open Access
• [Journal Article] Phase I trial of a cancer vaccine consisting of 20 mixed peptides in patients with castrate-resistant prostate cancer: dose-related immune boosting and suppression. (2015)
  • Author(s): Noguchi M, Arai G, Matsumoto K, Naito S, Moriya F, Suekane S, Komatsu N, Matsueda S, Sasada T, Yamada A, Itoh K.
  • Journal Title: Cancer Immunol Immunother. Volume: 64 Issue: 4 Pages: 493-505
  • DOI: 10.1007/s00262-015-1660-1
  • Peer Reviewed
• [Journal Article] Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens. (2015)
  • Author(s): Yamada T, Terazaki Y, Sakamoto S, Yoshiyama K, Matsueda S, Komatsu N, Waki K, Yamada A, Kawahara A, Kage M, Sugawara S, Yamashita Y, Sasada T, Takamori S, Itoh K.
  • Journal Title: Int J Oncol. Volume: 46 Issue: 1 Pages: 55-62
  • DOI: 10.3892/ijo.2014.2699
  • Peer Reviewed
• [Journal Article] Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer. (2014)
  • Author(s): Kibe S, Yutani S, Motoyama S, Nomura T, Tanaka N, Kawahara A, Yamaguchi T, Matsueda S, Komatsu N, Miura M, Hinai Y, Hattori S, Yamada A, Kage M, Itoh K, Akagi Y, Sasada T.
  • Journal Title: Cancer Immunol Res. Volume: 2 Issue: 12 Pages: 1154-1162
  • DOI: 10.1158/2326-6066.cir-14-0035
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility study of personalized peptide vaccination for metastatic recurrent triple-negative breast cancer patients. (2014)
  • Author(s): Takahashi R, Toh U, Iwakuma N, Takenaka M, Otsuka H, Furukawa M, Fujii T, Seki N, Kawahara A, Kage M, Matsueda S, Akagi Y, Yamada A, Itoh K, Sasada T.
  • Journal Title: Breast Cancer Res. Volume: 16 Issue: 4 Pages: 00-00
  • DOI: 10.1186/bcr3685
  • Peer Reviewed / Open Access
• [Journal Article] PD-1 expression on peripheral blood T-cell subsets correlates with prognosis in non-small cell lung cancer. (2014)
  • Author(s): Waki K, Yamada T, Yoshiyama K, Terazaki Y, Sakamoto S, Matsueda S, Komatsu N, Sugawara S, Takamori S, Itoh K, Yamada A.
  • Journal Title: Cancer Science Volume: 105(10) Issue: 10 Pages: 1229-35
  • DOI: 10.1111/cas.12502
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility study of personalized peptide vaccination for recurrent ovarian cancer patients. (2014)
  • Author(s): Kawano K, Tsuda N, Matsueda S, Sasada T, Watanabe N, Ushijima K, Yamaguchi T, Yokomine M, Itoh K, Yamada A, Kamura T.
  • Journal Title: Immunopharmacol Immunotoxicol. Volume: 36 Issue: 3 Pages: 224-236
  • DOI: 10.3109/08923973.2014.913617
  • Peer Reviewed / Open Access
• [Journal Article] The influence of Chlorella and its hot water extract supplementation on quality of life in patients with breast cancer. (2014)
  • Author(s): Noguchi N, Maruyama I, Yamada A.
  • Journal Title: Evid Based Complement Alternat Med Volume: 2014:704619 Issue: 1
  • DOI: 10.1155/2014/704619
  • Peer Reviewed / Open Access
• [Presentation] HMGB1 阻害剤はコアアジュバントとしてペプチドワクチンで誘導される抗腫瘍免疫を増強する (2016)
  • Author(s): 和氣 加容子、山田 亮
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 食道癌組織におけるT細胞レセプターレパートリーの包括的解析 (2016)
  • Author(s): 主藤 朝也、溝口 充志、河原 明彦、西田 良介、門屋 一貴、最所 公平、長主 祥子、森 直樹、的野 吾、田中 寿明、山田 亮、三森 功士、赤木 由人
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 血清抗前立腺関連抗原 (prostate-related antigen) 抗体価の乳癌ペプチドワクチン療法における臨床的意義に関する検討 (2016)
  • Author(s): 唐 宇飛、岩熊 伸高、岡部 実奈、朔 周子、赤司 桃子、赤木 由人、山田 亮、七條 茂樹、伊東 恭悟
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-10-06
• [Presentation] High mobility group box 1 (HMGB1) 阻害剤はコアアジュバントとしてペプチドワクチンで誘導される抗腫瘍免疫を増強する (2016)
  • Author(s): 和氣 加容子、山田 亮
  • Organizer: 第20回日本がん免疫学会総会
  • Place of Presentation: 大阪国際交流センター（大阪市）
  • Year and Date: 2016-07-27
• [Presentation] Randomized phase II trials of personalized peptide vaccination in advanced cancers (2016)
  • Author(s): ITO Kyogo、YUTANI Shigeru、SHICHIJO Sigeki、NOGUCHI Masanori、SASADA Tetsuro、YAMADA Akira、UEMURA Hirotsugu
  • Organizer: 第20回日本がん免疫学会総会
  • Place of Presentation: 大阪国際交流センター（大阪市）
  • Year and Date: 2016-07-27
• [Presentation] 去勢抵抗性前立腺癌に対する低用量シクロホスファミド併用ペプチドワクチン療法の第2相無作為比較試験 (2015)
  • Author(s): 野口正典、守屋普久子、古賀紀子、松枝智子、笹田哲朗、山田 亮、角間辰之、伊東恭悟
  • Organizer: 第28回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 川越東武ホテル（埼玉）
  • Year and Date: 2015-12-03
• [Presentation] テーラーメイドペプチドワクチン（PPV）療法と漢方の併用療法における免疫賦活能の検討 (2015)
  • Author(s): 古賀紀子、守屋普久子、松枝智子、和氣加容子、山田 亮、伊東恭悟、野口正典
  • Organizer: 第28回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 川越東武ホテル（埼玉）
  • Year and Date: 2015-12-03
• [Presentation] Feasibility studies of personalized peptide vaccination for advanced gynecologic cancer patients (2015)
  • Author(s): Kayoko Waki, Kouichiro Kawano, Testuro Sasada, Kimio Ushijima, Kyogo Itoh, Toshiharu Kamura, Akira Yamada
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Feasibility study of personalized peptide vaccination for cervical cancer patients who have received prior cisplatin-based chemotherapy (2015)
  • Author(s): Kayoko Waki, Kouichiro Kawano, Kyogo Itoh, Akira Yamada
  • Organizer: ICCIM 2015 (International Conference of Cancer Immunortherapy and Macrophages 2015)
  • Place of Presentation: 東京大学 伊藤謝恩ホール（東京都）
  • Year and Date: 2015-07-09
• [Presentation] Phase I trial of a cancer vaccine consisting of 20 mixed peptides in patients with castration-resistant prostate cancer : dose-related immune boosting and suppression. (2014)
  • Author(s): Noguchi M, Arai G, Matsumoto K, Naito S, Moriya F, Suekane S, Komatsu N, Matsueda S, Sasada T, Yamada A,Itoh K.
  • Organizer: 2014 WCC
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2014-12-03 – 2014-12-06
• [Presentation] ペプチドワクチンの最近の進歩 (2014)
  • Author(s): 伊東恭悟、野口正典、山田亮、七條茂樹、笹田哲朗、松枝智子、小松誠和
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25
• [Presentation] Lck由来新規Tヘルパーエピトープの同定 (2014)
  • Author(s): 松枝智子、七條茂樹、山田亮、笹田哲朗、伊東恭悟
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25
• [Presentation] 既二次治療進行非小細胞癌に対するテーラーメイドペプチドワクチン療法の臨床第Ⅱ相試験 (2014)
  • Author(s): 坂本信二郎、山田哲平、寺崎泰宏、吉山康一、松枝智子、小松誠和、和氣加容子、山田亮、菅原俊一、笹田哲朗、高森信三、伊東恭悟
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25
• [Presentation] Relationship between haptoglobin promoter polymorphism and peptide vaccine-induced immune responses in NSCLC patients (2014)
  • Author(s): 和氣加容子、山田哲平、寺崎泰宏、坂本信二郎、菅原俊一、高森信三、伊東恭悟、山田亮
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25
• [Presentation] PD-1 expression on peripheral blood T-cell subsets correlates with prognosis in non-small cell lung cancer (2014)
  • Author(s): 和氣加容子、山田哲平、吉山康一、坂本信二郎、松枝智子、小松誠和、菅原俊一、高森信三、伊東恭悟、山田亮
  • Organizer: 第18回日本がん免疫学会総会
  • Place of Presentation: ひめぎんホール（愛媛県松山市）
  • Year and Date: 2014-07-31
• [Presentation] 既二次治療進行非小細胞癌に対するテーラーメイドペプチドワクチン療法の臨床第Ⅱ相試験 (2014)
  • Author(s): 坂本信二郎、山田哲平、寺崎泰宏、吉山康一、松枝智子、小松誠和、和氣加容子、山田亮、河原明彦、鹿毛政義、菅原俊一、木下裕一、笹田哲朗、高森信三、伊東恭悟
  • Organizer: 第18回日本がん免疫学会総会
  • Place of Presentation: ひめぎんホール（愛媛県松山市）
  • Year and Date: 2014-07-31
• [Presentation] 去勢抵抗性前立腺がんを対象としたマルチペプチド混合カクテルワクチンKRM20の第Ⅰ相試験 (2014)
  • Author(s): 山田亮、野口正典、新井学、松本和将、内藤誠二、守屋普久子、末金茂高、小松誠和、松枝智子、笹田哲朗、伊東恭悟
  • Organizer: 第18回日本がん免疫学会総会
  • Place of Presentation: ひめぎんホール（愛媛県松山市）
  • Year and Date: 2014-07-31
• [Presentation] Randomized phase II study of personalized peptide vaccination with cyclophosphamide pretreatment in refractory advanced biliary tract cancer patients. (2014)
  • Author(s): Sasada T, Yutani S, Matsueda S, Shirahama T, Yamada A, Itoh K.
  • Organizer: 2014 ASCO Annual Meeting.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-06-01
• [Presentation] Randomized phase II study of personalized peptide vaccination in patients with advanced bladder cancer progressing after chemotherapy. (2014)
  • Author(s): Noguchi M, Matsumoto K, Uemura H, Arai G, Eto M, Naito S, Ohyama C, Nasu Y, Tanaka M, Moriya F, Suekane S, Matsueda S, Komatsu N, Sasada T, Yamada A, Itoh K.
  • Organizer: 2014 ASCO Annual Meeting.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-30 – 2014-06-03
• [Presentation] Randomized phase II study of personalized peptide vaccination with cyclophosphamide pretreatment in refractory advanced biliary tract cancer patients. (2014)
  • Author(s): Yutani S, Shirahama T, Komatsu N, Matsueda S, Sasada T, Yamada A, Itoh K.
  • Organizer: 12th CIMT (The Association for Cancer Immunotherapy) Annual Meeting.
  • Place of Presentation: Mainz, Germany
  • Year and Date: 2014-05-06 – 2014-05-08
• [Presentation] Randomized phase II study of personalized peptide vaccination in patients with advanced bladder cancer progressing after chemotherapy. (2014)
  • Author(s): Noguchi M, Moriya F, Suekane S, Matsueda S, Komatsu N, Sasada T, Yamada A, Itoh K.
  • Organizer: 12th CIMT (The Association for Cancer Immunotherapy) Annual Meeting.
  • Place of Presentation: Mainz, Germany
  • Year and Date: 2014-05-06 – 2014-05-08
• [Presentation] Phase II Clinical Trial of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer. (2014)
  • Author(s): Sasada T, Yutani S, Kibe S, Matsueda S, Komatsu K, Yamada A, Akagi Y, Itoh K.
  • Organizer: 12th CIMT (The Association for Cancer Immunotherapy) Annual Meeting.
  • Place of Presentation: Mainz, Germany
  • Year and Date: 2014-05-06 – 2014-05-08
• [Remarks] 久留米大学先端癌治療研究センター
  • URL: http://www.med.kurume-u.ac.jp/med/sentanca/
• [Remarks] 久留米大学先端癌治療研究センター
  • URL: http://www.med.kurume-u.ac.jp/med/sentanca/index.html
• [Patent(Industrial Property Rights)] コアジュバント組成物およびこれを含むワクチン組成物 (2016)
  • Inventor(s): 山田 亮、和氣 加容子
  • Industrial Property Rights Holder: 学校法人 久留米大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-08-09