Nucleosome formation and chromatin dynamics in microsatellite DNA sequences
| Project/Area Number |
26430186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | Meisei University |
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Principal Investigator |
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| Research Collaborator |
KAGAWA Wataru 明星大学, 理工学部, 准教授
KURUMIZAKA Hitoshi 早稲田大学, 理工学術院, 教授
MUKAI Yukio 長浜バイオ大学, バイオサイエンス学部, 准教授
KATO Hiroaki 島根大学, 医学部, 助教
FUSE Tomohiro 明星大学, 大学院・理工学研究科, 大学院生
KATSUMATA Koji 明星大学, 大学院・理工学研究科, 大学院生
MOROHOSHI Koya 明星大学, 大学院・理工学研究科, 大学院生
KURIHARA Yohei 明星大学, 大学院・理工学研究科, 大学院生
TESHIGAHARA Yuta 明星大学, 大学院・理工学研究科, 大学院生
HAYASHI Toshiki 明星大学, 大学院・理工学研究科, 大学院生
IMAI Koshi 明星大学, 大学院・理工学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ゲノム機能発現 / ヌクレオソーム / クロマチン / マイクロサテライト / 反復配列DNA / DNA構造 / 出芽酵母 |
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| Outline of Final Research Achievements |
Microsatellites are simple repeated DNA sequences that occupy about 3% of the human genome. The purpose of this study is to elucidate the structural and dynamic features of the chromatin in microsatellite DNA sequences. We focused on the triplet-repeat and disease-related repeat sequences, and systematically examined their effects on nucleosome formation and gene expression. Furthermore, we predicted nucleosome formation on these repeat sequences by a bioinformatics analysis. We identified the structural properties of repeated sequences that promote or inhibit nucleosome formation. These results provide new insights into the biological implications of microsatellites within chromosomes.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Cryogenic coherent x-ray diffraction imaging for biological non-crystalline particles using the KOTOBUKI-1 diffraction apparatus at SACLA2015
Author(s)
Tomotaka Oroguchi, Yuki Sekiguchi, Amane Kobayashi,Yu Masaki, Asahi Fukuda, Saki Hashimoto, Masayoshi Nakasako, Yuichi Ichikawa, Hitoshi Kurumizaka, Mitsuhiro Shimizu et al.,
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Journal Title
Journal of Physics B: Atomic, Molecular and Optical Physics
Volume: 48
Issue: 18
Pages: 184003-184003
DOI
Related Report
Peer Reviewed
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