Development of methods to provide information to assist personalized medical decision

• Project/Area Number: 26430192
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical genome science
• Research Institution: Kyoto University
• Principal Investigator: Yamada Ryo 京都大学, 医学研究科, 教授 (50301106)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 遺伝情報 / 個別化医療 / 意思決定 / 決断理論 / ベータ分布 / 決定理論 / ベイズ統計

Outline of Final Research Achievements

In the era of personalized medicine with big information, we investigated a clinical scenario where relatively small number of patients sequentially make their own decision based on the preceding outcomes. In the scenario, individual self-decision right should be respected and also the benefit for the whole population should be increased. To achieve both, we identified that heterogeneity in decision rules among individuals is important and also optimistic expectation-based decision rule is beneficial.

Research Products

• [Journal Article] Isotonic Regression Based-Method in Quantitative High-Throughput Screenings for Genotoxicity (2015)
  • Author(s): Fujii Y, Narita T, Tice RR, Takeda S, Yamada R
  • Journal Title: Dose-response Volume: 1 Issue: -1 Pages: 1-20
  • DOI: 10.2203/dose-response.13-045.fujii
  • NAID: 120005668062
  • Peer Reviewed
• [Journal Article] An association between anti-nuclear antibodies and HLA class II locus and heterogeneous characteristics of staining patterns: The Nagahama Study. (2014)
  • Author(s): Terao C, Ohmura K, Yamada R, Kawaguchi T, Shimizu M, Tabara Y, Takahashi M, Setoh K, Nakayama T, Kosugi S, Sekine A, Matsuda F, Tsuneyo Mimori T on behalf of the Nagahama Study Group.
  • Journal Title: Arthritis Rheumatol. Volume: 66 Issue: 3_suppl Pages: 3395-403
  • DOI: 10.1177/0022034514559127
  • Peer Reviewed / Open Access
• [Presentation] Benefits of Heterogeneity in Decision Making When Genetic Information is limited: Optimistic Self-Determination for Precision Medicine (2017)
  • Author(s): Wang J, Yamada R
  • Organizer: Human Genome Meeting (HGM) 2017
  • Place of Presentation: Hotel Barcelo Sants, Barcelona,Spain
  • Int'l Joint Research
• [Presentation] Comparison of two selection strategies based on genetic information when only small sample size is available (2016)
  • Author(s): Wang J, Yamada R
  • Organizer: The 13th International Congress of Human Genetics (ICHG)
  • Place of Presentation: Kyoto International Conference Center,Kyoto, Japan
  • Int'l Joint Research
• [Presentation] Evaluation of effects of self-decision selection strategies on the two-armed bandit problem to avoid wrong-side fixation (2015)
  • Author(s): Juan Wang, Ryo Yamada
  • Organizer: 2015 International Conference on Statistics and its Applications (ICSA 2015)
  • Place of Presentation: 上海
  • Year and Date: 2015-07-20
  • Int'l Joint Research