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Degeneration- and regeneration-inducing mechanism in neuronal axon

Research Project

Project/Area Number 26440008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Molecular biology
Research InstitutionWakayama Medical University

Principal Investigator

Hirai Syu-ichi  和歌山県立医科大学, 医学部, 教授 (80228759)

Co-Investigator(Renkei-kenkyūsha) YAMASAKI Hisashi  和歌山県立医科大学, 医学部, 准教授 (20212285)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords軸索 / 微小管 / シグナル伝達 / 大脳皮質 / 神経軸索 / 軸索再生 / 中枢神経 / 再生 / 神経 / 変性
Outline of Final Research Achievements

We investigated axon regeneration as well as axon formation in developing neurons, from a point of view of the function of a gene that we have identified as a key molecule for the development of mouse cerebrum. The results indicate that common molecular mechanisms function in the formation and the regeneration of axons, and that such mechanisms are regulated via different signaling pathways. These notions suggest a new approach to promote axon regeneration in damaged central nervous system, that is still challenging.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 2014 Other

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] A role for DLK in microtubule reorganization to the cell periphery and in the maintenance of desmosomal and tight junction integrity.2017

    • Author(s)
      Simard-Bisson C, Bidoggia J, Larouche D, Guerin SL, Blouin R, Hirai S, Germain L.
    • Journal Title

      J Invest Dermatol

      Volume: 137 Issue: 1 Pages: 132-141

    • DOI

      10.1016/j.jid.2016.07.035

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling2015

    • Author(s)
      Chen Q, Arai D, Kawakami K, Sawada T, Xuefeng Jing (京 雪楓), Miyajima M, Hirai S, Sakaguchi K
    • Journal Title

      PLoS One

      Volume: 1 Issue: 5 Pages: 1-24

    • DOI

      10.1371/journal.pone.0126942

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] DLK-dependent JNK activation facilitates the axon formation in cortical neurons.2017

    • Author(s)
      平井秀一
    • Organizer
      第60回 日本神経化学回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] DLK and JNK regulate the protein level of SCG10/stathmin-2 in cortical neurons.2017

    • Author(s)
      Hisashi Yamasaki, Masayasu Miyajima, Shigeo Ohno, Syu-ichi Hirai
    • Organizer
      2017年度 生命科学系学会合同年次大会 ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 軸索と樹状突起はその伸長過程において異なる量の微小管制御因子SCG10を要求する2016

    • Author(s)
      山﨑尚、宮嶋正康、大野茂男、平井秀一
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] DLK-JNK pathway regulates the timing for axon formation and dendrite outgrowth2015

    • Author(s)
      Yamasaki H, Miyajima M, Ohno S, Hirai S
    • Organizer
      BMB2015
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] マウスでのDLK-JNK経路に依存した軸索形成2014

    • Author(s)
      平井秀一
    • Organizer
      第5回 神経科学と構造生物学の融合研究会
    • Place of Presentation
      大阪大学蛋白質研究所(大阪府吹田市)
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] JNK依存的軸索形成における微小管制御因子SCG10の役割2014

    • Author(s)
      山﨑尚、大野茂男、平井秀一
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/med/lasbiology1/Biology_Index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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