Degeneration- and regeneration-inducing mechanism in neuronal axon
| Project/Area Number |
26440008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Hirai Syu-ichi 和歌山県立医科大学, 医学部, 教授 (80228759)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASAKI Hisashi 和歌山県立医科大学, 医学部, 准教授 (20212285)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 軸索 / 微小管 / シグナル伝達 / 大脳皮質 / 神経軸索 / 軸索再生 / 中枢神経 / 再生 / 神経 / 変性 |
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| Outline of Final Research Achievements |
We investigated axon regeneration as well as axon formation in developing neurons, from a point of view of the function of a gene that we have identified as a key molecule for the development of mouse cerebrum. The results indicate that common molecular mechanisms function in the formation and the regeneration of axons, and that such mechanisms are regulated via different signaling pathways. These notions suggest a new approach to promote axon regeneration in damaged central nervous system, that is still challenging.
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Report
(5 results)
Research Products
(9 results)
