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Elucidating the folding principles of the human genome

Research Project

Project/Area Number 26440010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Molecular biology
Research InstitutionWaseda University

Principal Investigator

Ohyama Takashi  早稲田大学, 教育・総合科学学術院, 教授 (60268513)

Research Collaborator YONEYAMA Hiroki  
YOSHIDA Kai  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsヒトゲノムDNA / ゲノムフォールディング / 染色体構築 / 間期染色体 / 分裂期染色体
Outline of Final Research Achievements

The purpose of this study is to elucidate the folding principles of the human genome. Based on the simulation of a chromatin loop structure in the chromosome 21 and subsequent comparison between the resulting model and the actual structure, we obtained a clue to the elucidation of the principles. It was strongly suggested that the fundamental structure of a chromatin loop is presumably determined by nucleosome positioning, conformations of linker DNAs, distance between the loop anchors and self-assembly of the nucleosomes with identical DNA sequences.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Magnesium chloride and polyamine can differentiate mouse embryonic stem cells into trophectoderm or endoderm.2017

    • Author(s)
      Tanase, J., Yokoo, T., Matsumura, Y., Kinoshita, M., Kikuchi, Y., Suemori, H. and Ohyama, T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 482 Issue: 4 Pages: 764-770

    • DOI

      10.1016/j.bbrc.2016.11.108

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ヒト間期染色体におけるクロマチンループの構造モデリング2016

    • Author(s)
      米山 大貴 , 大橋 拳登 , 大山 隆
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] 遺伝情報収納の基本原理2016

    • Author(s)
      大山隆
    • Organizer
      第6回都医学研シンポジウム「DNAとゲノム:二重らせん構造を超えて」
    • Place of Presentation
      新宿明治安田生命ホール
    • Related Report
      2016 Annual Research Report
  • [Presentation] Biological significance of cruciform structures as deduced by genome-wide analyses2016

    • Author(s)
      Osamu Miura , Hiroki Yoneyama , Takashi Ohyama
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト間期染色体におけるクロマチンループの微細構造モデル2015

    • Author(s)
      米山大貴, 吉田快, 三浦理, 山田修司, 大山隆
    • Organizer
      BMB2015(第38回日本分子生物学会年会,第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 塩基組成が二本鎖DNA分子の相同性認識と選択的集合に与える影響2015

    • Author(s)
      池田桃子, 黒田浩太郎, 荒井直樹, 大山隆
    • Organizer
      BMB2015(第38回日本分子生物学会年会,第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] メチル化が二本鎖DNA分子の相同性認識と選択的集合に与える影響2015

    • Author(s)
      黒田浩太郎, 池田桃子, 大山隆
    • Organizer
      BMB2015(第38回日本分子生物学会年会,第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] メチル化がDNAの自他識別能に与える影響2014

    • Author(s)
      清水貴行, 下岡保俊, 池田桃子, 大山隆
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Research-status Report
  • [Presentation] ヌクレオソームの自己集合においてDNAのメチル化は識別される2014

    • Author(s)
      下岡保俊, 清水貴行, 池田桃子, 大山隆
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Research-status Report
  • [Presentation] DNAの物理的特性に隠された情報と機能2014

    • Author(s)
      大山隆
    • Organizer
      日本分析化学会第63年会
    • Place of Presentation
      広島大学
    • Year and Date
      2014-09-18
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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