| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The purpose of this study is to elucidate the folding principles of the human genome. Based on the simulation of a chromatin loop structure in the chromosome 21 and subsequent comparison between the resulting model and the actual structure, we obtained a clue to the elucidation of the principles. It was strongly suggested that the fundamental structure of a chromatin loop is presumably determined by nucleosome positioning, conformations of linker DNAs, distance between the loop anchors and self-assembly of the nucleosomes with identical DNA sequences.
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