Elucidating the folding principles of the human genome
Project/Area Number |
26440010
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Molecular biology
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Research Institution | Waseda University |
Principal Investigator |
Ohyama Takashi 早稲田大学, 教育・総合科学学術院, 教授 (60268513)
|
Research Collaborator |
YONEYAMA Hiroki
YOSHIDA Kai
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | ヒトゲノムDNA / ゲノムフォールディング / 染色体構築 / 間期染色体 / 分裂期染色体 |
Outline of Final Research Achievements |
The purpose of this study is to elucidate the folding principles of the human genome. Based on the simulation of a chromatin loop structure in the chromosome 21 and subsequent comparison between the resulting model and the actual structure, we obtained a clue to the elucidation of the principles. It was strongly suggested that the fundamental structure of a chromatin loop is presumably determined by nucleosome positioning, conformations of linker DNAs, distance between the loop anchors and self-assembly of the nucleosomes with identical DNA sequences.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Magnesium chloride and polyamine can differentiate mouse embryonic stem cells into trophectoderm or endoderm.2017
Author(s)
Tanase, J., Yokoo, T., Matsumura, Y., Kinoshita, M., Kikuchi, Y., Suemori, H. and Ohyama, T.
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 482
Issue: 4
Pages: 764-770
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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