Regulation of SUMOylation dependent chromatin remoceling in heart development
| Project/Area Number |
26440015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Osaka University (2016)
National Institute of Information and Communications Technology (2014-2015) |
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Principal Investigator |
OGAWA Hidesato 大阪大学, 生命機能研究科, 特任准教授(常勤) (20370132)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Jun 東京大学, 分子細胞生物学研究所, 准教授 (10451999)
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| Research Collaborator |
TSUCHIYA Megumi 大阪大学, 生命機能研究科, 特任助教 (00390691)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | クロマチン構造変換 / 核内受容体 / 転写因子 / オートファジー / クロマチン / 転写制御 / 心筋分化 / 細胞周期 / 翻訳後修飾 / 核内構造体 / 転写複合体 |
|---|
| Outline of Final Research Achievements |
Transcriptional coregulators contribute to several processes involving nuclear receptor transcriptional regulation. The transcriptional coregulator androgen receptor-interacting protein 4 (ARIP4) interacts with nuclear receptors and regulates their transcriptional activity. In this study, we identified p62 as a major interacting protein partner for ARIP4 in the nucleus. Nuclear magnetic resonance analysis demonstrated that ARIP4 interacts directly with the ubiquitin-associated (UBA) domain of p62. ARIP4 and ubiquitin both bind to similar amino acid residues within UBA domains; therefore, these proteins may possess a similar surface structure at their UBA-binding interfaces. We also found that p62 is required for the regulation of ARIP4 protein levels under nutrient starvation conditions. We propose that p62 is a novel binding partner for ARIP4, and that its binding regulates the cellular protein level of ARIP4 under conditions of metabolic stress.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Lysosomal activity maintains glycolysis and cyclin E1 expression by mediating Ad4BP/SF-1 stability for proper steroidogenic cell growth2017
Author(s)
Syu JS, Baba T, Huang JY, Ogawa H, Hsieh CH, Hu JX, Chen TY, Lin TC, Tsuchiya M, Morohashi K, Huang BM, Lu FI
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 240-240
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-12014
Author(s)
Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
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Journal Title
Nature Commun
Volume: 5
Issue: 1
Pages: 3634-3634
DOI
Related Report
Peer Reviewed / Open Access
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