| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
A peroxisomal membrane protein Pex14p plays a pivotal role in peroxisomal matrix protein import. In this study, we found that Pex14p is phosphorylated upon oxidative stresses. Phosphorylation of Pex14p regulates import of peroxisomal matrix proteins, which can counteract cellular oxidative stresses. We also found that NDR2, a protein kinase involved in primary cilium formation, partially localized to peroxisomes in a manner dependent on its peroxisome-targeting signal-1-like sequence, Gly-Lys-Leu, at the C-terminus. Novel peroxisomal function is implicated in ciliogenesis and pathogenesis of ciliopathies.
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