| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We observed the change in the amount of PI(3,4,5)P3 and the activity of PI(3,4,5)P3 downstream signals in the epidermis of mice with psoriasis-like dermatitis. We also found signaling molecules involved in skin inflammation in phospholipase C(PLC) delta1 knockout mice. Our results contribute to understanding of the roles of PI(3,4,5)P3 and PLC delta1 downstream signals in psoriasis-like dermatitis.
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