The role of phospholipid metabolism in skin diseases
Project/Area Number |
26440036
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Structural biochemistry
|
Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
|
Research Collaborator |
NAKANISHI Hiroki
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 皮膚 / ケラチノサイト / ホスホリパーゼ / イノシトールリン脂質 / ホスホリパーゼC / PLC / 皮膚炎 / 表皮角化細胞 |
Outline of Final Research Achievements |
We observed the change in the amount of PI(3,4,5)P3 and the activity of PI(3,4,5)P3 downstream signals in the epidermis of mice with psoriasis-like dermatitis. We also found signaling molecules involved in skin inflammation in phospholipase C(PLC) delta1 knockout mice. Our results contribute to understanding of the roles of PI(3,4,5)P3 and PLC delta1 downstream signals in psoriasis-like dermatitis.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.2017
Author(s)
Kaori Kanemaru, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami
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Journal Title
Cell Death & Differentiation
Volume: in press
Issue: 6
Pages: 1079-1090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.2015
Author(s)
1.Kudo, K., Uchida, T., Sawada, M., Nakamura, Y., Yoneda, A., and Fukami K.
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Journal Title
Adv. Biol. Regul.
Volume: S2212-4926(15)30022-1
Pages: 68-79
DOI
Related Report
Peer Reviewed / Open Access
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