| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In recent years, many protein complexes involved in epigenetic gene control were genetically identified. Interestingly, a plant-specific protein complex participating in the regulation contains a hinge-like domain commonly found in proteins, which are involved in eukaryotic chromosome condensation. I investigated the structural relationship of the domain found over these two systems. The crystal structure of the hinge domain of the bacterial SMC protein reveals an asymmetric dimer with a half-opened interface, clarifying involvement of the domain for conformational changes of the overall structure within the SMC complex. I also identified minimal components of the plant-specific complex essential for the stable association to aim further structural analysis.
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