Mechanisms of large cargoes secretion
Project/Area Number |
26440046
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
SAITO KOTA 東京大学, 大学院薬学系研究科(薬学部), 助教 (60549632)
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Co-Investigator(Renkei-kenkyūsha) |
KATADA TOSHIAKI 武蔵野大学, 薬学部, 教授 (10088859)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 分泌 / 小胞体 / コラーゲン / ER exit site / COPII / 低分子量Gタンパク質 |
Outline of Final Research Achievements |
The mechanisms of collagen secretion have not been well characterized, because collagens synthesized within the ER are too large to fit into conventional COPII-coated vesicles. We previously characterized TANGO1 as a collagen cargo receptor. In this study, we have characterized that TANGO1 forms macromolecular complexes with cTAGE5 and TANGO1. In addition, we have revealed that TANGO1 acts as a scaffold in corporation with Sec16 and functions as an organizer of ER exit site. We have also identified Sec23a as a protein up-regulated during hepatic stellate cell activation. When Sec23a is depleted, activation of hepatic stellate cells is attenuated.
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Report
(5 results)
Research Products
(25 results)
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[Presentation] 生理的および肝線維化時におけるコラーゲン分泌機構の解析2015
Author(s)
齋藤 康太、前田 深春、篠原 健太朗、堅田 利明.
Organizer
BMB2015 第38回日本分子生物学会年会第88回日本生化学会大会合同年会
Place of Presentation
神戸ポートアイランド(兵庫県・神戸市)
Year and Date
2015-12-03
Related Report
Int'l Joint Research / Invited
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