Mechanism for regulation of bacterial genes to escape from phagocytosis for persistent infection in host
| Project/Area Number |
26440049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自然免疫 / 細菌 / 細胞貪食 / 遺伝子発現 / 感染症 / 貪食 / ショウジョウバエ |
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| Outline of Final Research Achievements |
Bacteria under hostile environmental conditions alter their gene expression to adapt and survive in the host. This study identified genes in Escherichia coli that acted for regulation of virulence in host with aid of the two-component regulatory system EnvZ-OmpR. Among sigma factors, we reported that RpoS, a type of RNA polymerase sigma factors in E. coli, induced expression of bacterial catalases for inhibition of phagocytic killing in host. In this study, we found that RpoS raised in host in a manner of post-transcriptional regulation for persistence in host.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Inhibition of Phagocytic Killing of Escherichia coli in Drosophila Hemocytes by RNA Chaperone Hfq.2016
Author(s)
Shiratsuchi, A., Nitta, M., Kuroda, A., Komiyama, C., Gawasawa, M., Shimamoto, N., Tuan, T. Q., Morita, T., Aiba, H.,and Nakanishi, Y.
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Journal Title
J. Immunol.
Volume: 197
Issue: 4
Pages: 1298-1307
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Peptidoglycan recognition protein-triggered induction of Escherichia coli gene in Drosophila melanogaster2015
Author(s)
Kong, Q., Nakai, Y., Kuroda, N., Shiratsuchi, A., Nagaosa, K., and Nakanishi, Y.
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Journal Title
J. Biochem.
Volume: 00
Issue: 6
Pages: 00-00
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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