| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We have developed ERroGFP S4 which could visualize ER redox states and elucidated the mechanism by which an ER disulfide reductase, ERdj5 received reductive power in an oxidative environment of the ER and promoted degradation of misfolded proteins. We found that ERdj5 is localized near ER membrane where the redox state is more reducing than that in the ER lumen. Therefore, ERdj5 efficiently received reductive power of reduced glutathione derived from cytosol and promoted ERAD.
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