Molecular mechanism of TORC1 activity and function in meiosis using a model organism.
| Project/Area Number |
26440053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kobe University |
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Principal Investigator |
Nakashima Akio 神戸大学, バイオシグナル総合研究センター, 准教授 (70397818)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | TORC1 / 減数分裂 / シグナル伝達 / モデル生物 / 分裂酵母 |
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| Outline of Final Research Achievements |
The Target of rapamycin complex 1 (TORC1) protein kinase plays a critical role of several cellular controls in response to environmental inputs, including nutrients. In this study, we examined the mechanism of TORC1 regulation and its functions during meiosis even under nitrogen starvation using a model organism, the fission yeast Schizosaccharomyces pombe. We showed that TORC1 activity is substantially increased when cells enter meiotic phase under nitrogen starvation and two molecules involving meiotic progression are important for the TORC1 regulation in meiosis. TORC1 was required for meiotic progression though the regulation of gene transcription. The findings obtained in this study propose a novel molecular model of the regulation and function of TORC1 in meiosis in a wide range of eukaryotic organisms.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.2016
Author(s)
Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K.
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Journal Title
Nucleic Acids Res.
Volume: 44
Issue: 18
Pages: 8704-8713
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Identification of Regions Critical for the Integrity of the TSC1-TSC2-TBC1D7 Complex.2014
Author(s)
Santiago, Lima, A.J., Hoogeveen-Westerveld, M., Nakashima, A., Maat-Kievit, A., van den Ouweland, A., Halley, D., Kikkawa, U., and Nellist, M.
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Journal Title
PLoS One
Volume: 9
Issue: 4
Pages: e93940-e93940
DOI
Related Report
Peer Reviewed / Open Access
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