The analysis of the molecular mechanism of amphibian metamorphosis using genomic editing
| Project/Area Number |
26440057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Yaoita Yoshio 広島大学, 両生類研究センター, 教授 (00166472)
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| Co-Investigator(Kenkyū-buntansha) |
田澤 一朗 広島大学, 両生類研究センター, 助教 (10304388)
中島 圭介 広島大学, 両生類研究センター, 助教 (60260311)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 変態 / 甲状腺ホルモン / 両生類 / げっ歯類 / 脳の変態 / 肝臓の変態 / 出生 / ネッタイツメガエル / 無尾両生類 / ゲノム編集 / 甲状腺ホルモン受容体 / TALEN / 細胞外基質分解酵素 |
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| Outline of Final Research Achievements |
We have examined whether the birth of the mammalian newborn corresponds to metamorphosis. In rodent, the surge of thyroid hormone is observed in the first three postnatal weeks. Eleven genes up-regulated in the brain of Xenopus tropicalis during metamorphosis were analyzed in detail and their expression levels increased in the rodent brain during three postnatal weeks. The expression of six genes encoding proteins up-regulated in mouse brain during the three postnatal weeks was also induced in the tadpole brain during metamorphosis. These data indicate that the similar gene expression profile to that of metamorphosing tadpole brain was elicited in rodent brain and strongly suggested that the rodent brain undergoes metamorphosis.
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Report
(5 results)
Research Products
(42 results)
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[Journal Article] Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients2015
Author(s)
Takuya Nakayama, Marilyn Fisher, Keisuke Nakajima, Akinleye O. Odeleye, Keith B. Zimmerman, Margaret B. Fish, Yoshio Yaoita, Jena L. Chojnowski, James D. Lauderdale, Peter A. Netland, Robert M. Grainger
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Journal Title
Developmental Biology
Volume: 408
Issue: 2
Pages: 328-344
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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