| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
There is a growing body of evidence that hypothalamic inflammation precedes development of diet-induced obesity and disrupted hypothalamic control of feeding, but the detailed molecular mechanism of the response remains incompletely understood. Here we found enhanced expressions of several genes responsible for ganglioside synthesis in the hypothalamus of high-fat diet-fed mice. We also found that deficiency of ganglioside GM3 synthase gene improved responsiveness to leptin in the hypothalamus of obese mouse model which develops leptin resistance, resulting in improvements in the body weight and food intake as well as the glucose and insulin tolerance.
|
