Analysis of the physiological roles of gangliosides in the control of feeding and metabolism
| Project/Area Number |
26440061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ガングリオシド / 視床下部 / レプチン抵抗性 / メラノコルチン受容体 / スフィンゴ糖脂質 / GM3 / レプチン受容体 / レプチン / 炎症 / 受容体シグナル |
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| Outline of Final Research Achievements |
There is a growing body of evidence that hypothalamic inflammation precedes development of diet-induced obesity and disrupted hypothalamic control of feeding, but the detailed molecular mechanism of the response remains incompletely understood. Here we found enhanced expressions of several genes responsible for ganglioside synthesis in the hypothalamus of high-fat diet-fed mice. We also found that deficiency of ganglioside GM3 synthase gene improved responsiveness to leptin in the hypothalamus of obese mouse model which develops leptin resistance, resulting in improvements in the body weight and food intake as well as the glucose and insulin tolerance.
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Report
(4 results)
Research Products
(11 results)
