| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
It is well established that genetic mutations of Ras genes are involved in many cases of tumorigenesis. In this study, we found that a member of Ras family, kappaB-Ras contributes to the cellular transformation mediated the activation of protein kinase mTORC1. Furthermore, we purified the protein complexes including kappaB-Ras, and found that TRB3 which is identified as an interacting protein of kappaB-Ras functions as novel type of tumor suppressor. Although detailed mechanism is still unclear, it is clarified that TRB3 suppresses the oncogenic signals mediated the SUMO-conjugation of kappaB-Ras.
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