Analysis of oncogenic signals regulated by novel type of Ras family protein
| Project/Area Number |
26440062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Jichi Medical University |
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Principal Investigator |
Tago Kenji 自治医科大学, 医学部, 講師 (20306111)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Rasファミリー / 低分子量G蛋白質 / 発がんシグナル / がん抑制遺伝子 / SUMO化 |
|---|
| Outline of Final Research Achievements |
It is well established that genetic mutations of Ras genes are involved in many cases of tumorigenesis. In this study, we found that a member of Ras family, kappaB-Ras contributes to the cellular transformation mediated the activation of protein kinase mTORC1. Furthermore, we purified the protein complexes including kappaB-Ras, and found that TRB3 which is identified as an interacting protein of kappaB-Ras functions as novel type of tumor suppressor. Although detailed mechanism is still unclear, it is clarified that TRB3 suppresses the oncogenic signals mediated the SUMO-conjugation of kappaB-Ras.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression2016
Author(s)
Watanabe K, Nakayama K, Ohta S, Tago K, Boonvisut S, Millings EJ, Fischer SG, LeDuc CA, Leibel RL, Iwamoto S.
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Journal Title
Biochem Biophys Res Commun
Volume: 477
Issue: 4
Pages: 712-716
DOI
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Peer Reviewed / Int'l Joint Research
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[Journal Article] NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia-Reperfusion Injury Independently of Inflammasomes.2014
Author(s)
Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki, Nishimura S, Sagara J, Noda T, IwakuraY, Hiroko Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.
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Journal Title
J Immunol
Volume: 192(9)
Issue: 9
Pages: 4342-4351
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] K-Ras遺伝子の新しい突然変異は発がん活性を示す2016
Author(s)
Kenji Tago, Megumi Funakoshi-Tago, Satoshi Ohta, Jitsuhiro Matsugi, Ken Yanagisawa
Organizer
第39回日本分子生物学会年会
Place of Presentation
パシフィコ横浜（神奈川県・横浜市）
Year and Date
2016-11-30
Related Report
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