Serum amyloid A3 and intracellular signaling protein mTOC
| Project/Area Number |
26440063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
Tomita Takeshi 東京女子医科大学, 医学部, 助教 (20302242)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血清アミロイド / セラストラマイシン / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
In this study, structure and functions of human serum amyloid A3 (SAA3) were studied. Although DNA sequence of human SAA3 is very similar to that of mouse SAA3, human SAA3 C terminal amino acid sequence is quite different due to single nucleotide insertion in human SAA3 gene. Human SAA3 specific antibodies were produced by using the C terminus peptide as an antigen. Then, the antibodies were utilized to detect SAA3 contained in culture media. These data were published in an open access journal. The researcher also reported basic analysis of Celastramycin A binding protein (mTOC), known as ZFC3H1. Further analysis of mTOC binding protein was executed to find out that some nuclear proteins including MTR4 were assigned to be mTOC binding factors.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor2014
Author(s)
Tomita T, Ieguchi K, Coin F, Kato Y, Kikuchi H, Oshima Y, Kurata S, Maru Y
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Journal Title
PLoS One
Volume: 30
Issue: 9
Pages: e108957-e108957
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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