Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
Invadopodia in invasive cancer cells are actin-enriched structures with an ability to degrade extracellular matrix (ECM) and play crucial roles in invasion and metastasis. Membrane-type matrix metalloproteinase, MT1-MMP, is a major molecule that mediates ECM degradation at invadopodia and has been thought to be transported to invadopodia through several intracellular trafficking pathways. However, its molecular mechanisms remains elusive. In this study, we comprehensively identified several SNARE proteins as a membrane fusion machinery for MT1-MMP trafficking and invadopodia formation and revealed the roles of the SNAREs and their regulatory factor.
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