| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The results obtained in this study suggested that RECQL5 removes stacked RNA polymerase to avoid generation of DNA lesions. In addition, RECQL5 plays role in the process to deal with DNA lesions induced by aldehydes. In the case of RecQ helicase related protein, WRNIP1, it was suggested that WRNIP1 functions to regulate the translesion DNA polymerase, DNA polymerase η, and that when both protein are absent, a novel pathway involving Polδ and PrimPol begins to function. In addition, WRNIP1 controls the expression of PrimPol.
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